美国佐治亚州亚特兰大使用高通量DNA条形码筛选开发靶向基因编辑疗法的博士后和技术员职位

The Dahlman Lab (dahlmanlab.org, @DahlmanLab) at Georgia Tech and Emory Medical School has developed a novel method to measure how many nanoparticles deliver drugs simultaneously. For the first time, we can evaluate how thousands of distinct nanoparticles deliver DNA- or RNA-based drugs directly in mice (instead of evaluating them in cell culture). As an example, we can generate ~2,000 in vivo drug delivery data points in a single experiment.

We are hiring a post-doc with a Ph.D. in chemistry or chemistry-related field. We are also hiring a research technician (B.S. or M.S.) with experience in molecular biology, biological engineering, biotechnology, or genomics. The post-doc will synthesize novel polymer-, peptide-, or lipid-based compounds, and will evaluate these compounds as drug delivery vehicles in vivo. The research technician will help lead in vivo studies, which include tissue isolation, FACS, DNA isolation, DNA sequencing, and analyzing Cas9-mediated gene editing. Our goal is to identify nanoparticles that deliver therapeutic siRNA, mRNA, or gene editing therapies to new tissues.

Both the post-doc and technician will quickly generate several papers and patents. Our work is high-paced and translational. We have access to clinical partners interested in translating our work.

This is a unique opportunity for several reasons. First, you will be a member of a dynamic, fun, diverse, and interdisciplinary group. Second, you will learn about new high throughput nanoparticle screening technologies. You will combine high throughput chemistry, nanoparticle characterization, genomics, RNA therapeutics, gene editing, and genomics. Third, you will be working in a cutting-edge field (gene editing) developing clinically relevant technologies. Finally, the Georgia Tech / Emory Medical School Department of Biomedical Engineering is ranked #1 and #2 for undergraduate and graduate studies, respectively. It is located in Atlanta. Atlanta is a thriving city with major cultural, professional, and athletic institutions. This ‘city in a forest’ is welcoming, and offers great food / music / breweries / hiking / biking, warm weather, and an excellent quality of life. A standard scientific salary goes a lot farther in Atlanta than other major cities.

Applicants should email a CV to james.dahlman@bme.gatech.edu. The positions can start as early as July 1st. We encourage applicants to apply quickly.

Keywords: Cas9, gene editing, CRISPR, nanoparticle, nanotechnology, chemistry, chemist, technician, post-doc, clinical, sequencing, genomics, LNP, siRNA, RNAi, RNA therapies, DNA barcode…