美国约翰霍普金斯大学招聘生物化学或者电生理学相关博士后

A postdoctoral associate position is available to study the molecular and genetic basis of sleep in Drosophila. We use sophisticated genetic approaches in the fruit fly to study the genes and circuitry underlying sleep, a fundamental and evolutionary conserved behavior. We are currently studying 1) the mechanisms underlying sleep homeostasis, 2) the function of sleep in neural plasticity, and 3) specific dopaminergic circuits that modulate behavior in response to internal states. To carry out these studies, we combine molecular and genetic approaches with high throughput behavioral analyses, immunohistochemical techniques, in vivo patch-clamp electrophysiology, and in vivo functional imaging. Applicants should have a Ph.D. and/or M.D. and be energetic, creative, and highly motivated. Background in biochemistry, electrophysiology, and/or systems biology is desirable. For more information, see our website: www.markwulab.net.

Representative publications:
1. Liu, S.#, Lamaze, A.#, Liu, Q., Tabuchi, M., Yang, Y., Fowler, M., Bharadwaj, R., Zhang, J., Bedont, J., Blackshaw, S., Lloyd, T.E., Montell, C., Sehgal, A., Koh, K.#, and Wu, M.N.# (2014). WIDE AWAKE Mediates the Circadian Timing of Sleep Onset. Neuron 82, 151-166.

2. Liu, Q., Liu, S., Kodama, L., Driscoll, M., and Wu, M.N. (2012). Two Dopaminergic Neurons Signal to the Dorsal Fan-shaped Body to Promote Wakefulness in Drosophila. Curr. Biol. 22, 2114-2123.

3. Wu, M.N.#, Joiner, W.J.#, Dean, T.#, Smith, C., Yue, Z., Hoshi, T., Sehgal, A.S., and Koh, K. (2010). Sleepless Regulates Shaker Expression, Localization, and Function. Nature Neurosci. 13, 69-75.

4. Koh, K.#, Joiner, W.J.#, Wu, M.N.#, Yue, Z., Smith, C., and Sehgal, A.S. (2008). Identification of Sleepless, a Sleep Promoting Factor. Science 321, 372-376.

Please send cover letter, CV, and the names of three references to marknwu@jhmi.edu…