美国H. Lee Moffitt癌症中心与研究所癌症药物研发博士后职位

美国H. Lee Moffitt癌症中心与研究所癌症药物研发博士后职位

Postdoctoral Fellow in Cancer Drug Discovery

H. Lee Moffitt Cancer Center & Research Institute

The Duckett lab is seeking to hire highly motivated postdoctoral fellows in the department of Drug Discovery at the H. Lee Moffitt Cancer Center and Research Institute in Tampa, Florida. There are two openings available.

The main focus of the lab is identifying novel anti-cancer targets, developing, new selective molecular probes of these targets as tools to interrogate how their altered signaling drives tumor progression, metastasis, therapy resistance and mechanisms of immune escape. Using pharmaceutical practices, we aim to optimize these new probes as potential therapeutics.  The successful candidate will be involved in an exciting new project to determine the mechanism of how aberrant regulation of kinase signaling may trigger immunosuppressive myelopoieisis and T-cell dysfunction and how this may be exploited as new anti-cancer treatments.

Responsibilities:

•This individual will perform investigational studies using human cell lines, primary patient derived spheriods and tumor samples.

•Designing and perform experiments independently and analyze data.

•Identify and validate targets from existing RNA seq and proteomic data sets.

•Perform experiments aimed at elucidating compound mechanism of action.

•Participate in data interpretation and crafting manuscripts for publication.

Req# 43376 – Immune Microenvironment

Position Highlights:

•The position is for a Postdoctoral fellow to join an interdisciplinary team to interrogate signal transduction pathways relating to altered transcription, immune checkpoints and cancer.

•Opportunity to gain drug discovery experience to lead a research project and studies to investigate signaling and the cancer immune microenvironment.

The Ideal Candidate:

Successful candidates will have a strong background in cancer immunology with a keen interest in drug discovery research.

•Prior experience is required with some of the following techniques:

o        mammalian cell culture.

o             isolation of immune cell populations.

o    multi parameter flow cytometery, sample preparation and data   acquisition.

o        biochemistry/ enzymology.

o        drug discovery cell-based assay development.

o        molecular and cell biology.

o        experience in vivo mouse efficacy studies.

o        candidates with prior experience in cancer immunology will be given preference.

o        excellent oral and written communication skills are required.

•while experience in the above skills is highly preferred, applicants with related skills set are encouraged to apply.

Credentials and Qualifications:

•MD or PhD in Immunology, Molecular Biology, Biochemistry, or relevant field.

Req# 44730 – Chemical Biology

Position Highlights:

•The position is for a Postdoctoral fellow to join an interdisciplinary team to develop new agents designed to modulate targets previously considered difficult to drug

•Opportunity to gain drug discovery experience, conduct independent research in chemical biology and develop new compounds with novel mechanism of action to interrogate oncogenic signaling pathways.

The Ideal Candidate:

Successful candidates will have a strong background in cancer biology with a keen interest in drug discovery research.

•Prior experience is required with some of the following techniques: •mammalian cell culture.

•experience in chemical biology techniques.

•biochemistry/ enzymology.

•drug discovery cell-based assay development.

•molecular and cell biology.

•experience in vivo mouse efficacy studies.

•excellent oral and written communication skills are required while experience in the above skills is highly preferred, applicants with related skills set are encouraged to apply.

Credentials and Qualifications:

•MD or PhD in chemical biology, molecular biology, biochemistry, or relevant field.

How to Apply: Please go to the Moffitt Careers site and apply to the requisition of interest.

https://moffitt-cancer-center-careers.hctsportals.com/search/postdocs-and-fellows/jobs

Interested applicants should include a single PDF file by email that includes:

•a cover letter summarizing outlining candidate’s motivations and suitability

•a summary of research accomplishments (4 pages maximum)

•current CV with recent publications and contact information for three references

For questions regarding the opportunity, please contact Dr. Derek Duckett’s office via email – Melissa.Meister@Moffitt.org

You will be eligible for benefits offered to our Team Members – Medical, Dental, Vision, Paid Time Off, Retirement, Parental Leave and more. With a move to Tampa, you may be eligible for relocation allowance. Reason to relocate, aside from the sunshine, beaches and year-round outdoor recreation associated with the Gulf Coast of Florida, Tampa is a thriving metropolitan city with unique cultural attractions, low cost of living and a high quality of life. We strive for work/life balance.

If you have the vision, passion, and dedication to contribute to our mission,

then we have a place for you.

Equal Employment Opportunity

Moffitt is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, or protected veteran or disabled status. Moffitt seeks candidates whose skills, and personal and professional experience, have prepared them to contribute to our commitment to diversity and excellence.