美国密歇根大学癌症表观遗传学博士后职位

美国密歇根大学癌症表观遗传学博士后职位

University of Michigan: RESEARCH FELLOW in cancer epigenetic

How to Apply

Please submit cover letter, CV, and contact information for 2-3 references combined into one PDF file by e-mail to: tomaszc@umich.edu or rjhryan@med.umich.edu.

Contact: Tomasz Cierpicki, PhD, Associate Professor

Department of Pathology, University of Michigan

Ann Arbor, MI, 48109, USA

Https: // www. pathology.med.umich.edu/index.php?t=page&id=1473

E-mail: tomaszc@umich.edu

Job Summary

Postdoctoral position in biomedical science is available in Prof. Tomasz Cierpicki and Prof. Russell Ryan laboratories, University of Michigan, Ann Arbor, to carry out cancer epigenetic projects focused on studying the effect of small molecules blocking new epigenetic targets and to pursue target validation studies using genetic approaches.

Mission Statement

Michigan Medicine improves the health of patients, populations and communities through excellence in education, patient care, community service, research and technology development, and through leadership activities in Michigan, nationally and internationally. Our mission is guided by our Strategic Principles and has three critical components; patient care, education and research that together enhance our contribution to society.

Responsibilities

The research will focus on evaluation of the activity and the mechanism of action of novel small molecules blocking epigenetic proteins in cancer as well as evaluation of epigenetic and functional effects of perturbing chromatin regulatory proteins in cancer. This position requires the expertise in cell biology and molecular biology techniques, including PCR, qRT-PCR, Western Blotting, co-Immunoprecipitation, ChIP, ChIPSeq, flow cytometry, CRISPR-based “epigenome editing”. Prior work experience with animals such as transgenic mice and xenograft models of cancer would be a plus. Successful candidate will be a part of an interdisciplinary team focused on development and pre-clinical evaluation of novel anti-cancer drug candidates.

Successful candidate will be co-mentored by Drs Cierpicki and Ryan. We offer highly interdisciplinary training in cancer epigenetics that will cover stat- of-the art epigenomic techniques combined with modern tools in chemical biology and drug discovery (e.g. protein-protein interaction inhibitors and PROTACs).

Required Qualifications

Applicant must have PhD in biology or related field. The candidates must be a first author on at least 2-3 publications. This position requires extensive experience in cell and molecular biology techniques. Furthermore, excellent oral and written communication skills in English are required as well as the ability to conduct independent scientific investigations.

Additional Information

Relevant publications

  Klossowski S, et al. Cierpicki T, Grembecka J. (2019) Menin inhibitor MI-3454 induces remission in MLL1-rearranged and NPM1-mutated models of leukemia. J Clin Invest. 130(2):981-997

  Ryan RJH, et al: A B Cell Regulome Links Notch to Downstream Oncogenic Pathways in Small B Cell Lymphomas. Cell reports. 2017; 21(3):784-797

  Huang H. et al, Cierpicki T. Covalent Inhibition of NSD1 histone methyltransferase. Nature Chem. Biol. In pressBackground Screening

Michigan Medicine conducts background screening and pre-employment drug testing on job candidates upon acceptance of a contingent job offer and may use a third party administrator to conduct background screenings. Background screenings are performed in compliance with the Fair Credit Report Act. Pre- employment drug testing applies to all selected candidates, including new or additional faculty and staff appointments, as well as transfers from other U-M campuses.

Application Deadline

Job openings are posted for a minimum of seven calendar days. The review and selection process may begin as early as the eighth day after posting. This opening may be removed from posting boards and filled anytime after the minimum posting period has ended.