当前位置:知识人网 >> 国外博士后招聘 >> 正文内容

比利时临床蛋白质组学博士后职位
文章来源:知识人网整理       更新时间:2020年01月20日

比利时临床蛋白质组学博士后职位

Job description

Given the epidemiological forecast and the failure of clinical treatments, there is a clear need to detect Alzheimer’s disease (AD) in the preclinical phase to prevent or delay its further development. Nowadays, AD diagnosis relies on a combination of biomarkers obtained from imaging and on the levels of tau and Aβ peptides in cerebrospinal fluid. Blood biomarkers as first screening tools are of high interest as these are cost- and time-effective, obtained in a minimally invasive manner and allow for repeated sampling (e.g., to monitor disease evolution).

Though there have been several untargeted proteome studies aimed at identifying protein biomarkers in the blood of AD patients, no such protein signature was found which, with sufficient sensitivity and reproducibility, could distinguish between AD, mild cognitive impairment (MCI) and controls. Selective enrichment of plasma Aβ peptides strongly indicates that Aβ burden might be a good biomarker to distinguish AD patients from controls. We hypothesize that if plasma Aβ burden reflects brain pathology, detecting other brain proteins in blood samples is a matter of applying a sufficiently sensitive method.

We have developed a novel proteomic technology that enriches for proteins that get deposited into the fluids surrounding diseased tissues, this upon cytolysis of parts of such tissues. In this project, in collaboration with clinical centres, we will collect and analyse blood samples from AD-dementia patients, MCI individuals and cognitively normal controls with the aim to identify novel AD biomarkers.

Profile

Essential

Candidates should hold a doctoral degree in life sciences and are junior postdoctoral researchers with a proven track record in applying mass spectrometric techniques, preferentially in biomedical/clinical settings. Candidates must have been involved in all aspects of contemporary proteomics, including sample preparation, analysis by means of mass spectrometry and bioinformatics to identify and quantify proteins. Excellent knowledge of the English language is a prerequisite.

Desirable but not required

Eligible candidates with excellent grades/an excellent CV will be strongly encouraged to apply for their own fellowships once they started to work in the Gevaert lab.

Candidates with a track record in using proteomics for the identification of disease biomarkers and/or the study of neurodegenerative diseases are strongly encouraged to apply.

Experience with data-independent analyses is an asset, as is your motivation to get involved in teaching master-level students.

Key personal characteristics

We will hire an enthusiastic, warm and motivated young postdoctoral scientist who considers science as her/his playground! You must be able to communicate with clinicians as well as with proteome scientists, bioinformaticians and statisticians.

We offer

A very warm working environment in a brand new science building (Q1 2020) that brings together about 700 life science scientists in the biotechnology hub in Flanders, the medieval city of Ghent.

The position will start in 2020 and will last for at least two years.

How to apply?

Motivated candidates are asked to apply online.


扫一扫知识人网官方微信订阅号,更多最新学术资讯、博士后招聘信息 一手掌握!国外博士后、访问学者申请免费专业评估,专家答疑解惑,一键关注离世界顶尖大学一步之遥!

快速申请国外博士后(免费评估)


点击这里快速申请国外博士后

点击这里快速申请国外访问学者

知识人网拥有10余年专职国外博士后、访问学者职位服务经验;
世界30000多所大学、研究机构职位机会,学术研究职位专业服务机构;
资深专业顾问将竭诚为博士精英们提供最优质的服务,实现您梦想的阶梯;
全国免费电话欢迎垂询:400-060-0581 直拨电话:010-68168664/68228237/68161776/68227792