莫菲特癌症研究所蛋白质生物化学与分子生物学博士后招聘

　　莫菲特癌症研究所蛋白质生物化学与分子生物学博士后招聘

　　The laboratory of Dr. Vincent Luca is seeking postdoctoral researchers interested in: (1) studying the structural mechanisms of Notch receptor activation and (2) designing synthetic protein ligands to control Notch activity on specific tissue or cell types. We use a multidisciplinary approach that integrates structural and cellular biology with cutting edge protein engineering techniques, such as directed evolution, to understand signaling mechanisms at the molecular level. These projects incorporate both basic and translational research, and Notch-targeted biologics will be evaluated as potential therapies for autoimmunity, developmental disorders, and cancer. Candidates will work with a team of immunologists, tumor biologists, and clinicians at Moffitt Cancer Center (Tampa, FL) to conduct research in a highly collaborative environment. The positions are funded for up to 5 years by a R35 MIRA grant from the NIH/NIGMS.

　　Position Highlights:

　　• Structure-function studies of Notch receptor signaling mechanisms

　　• Design biologics using protein engineering & directed evolution

　　• Collaboratively assess therapeutic potential of biologics in disease models

　　The Ideal Candidate:

　　• Has demonstrated expertise in protein biochemistry and molecular biology

　　• Expertise in x-ray crystallography or other structure determination methods is preferred

　　Responsibilities:

　　• Protein purification, biophysical characterization of protein-protein interactions, directed evolution, x-ray crystal structure determination, cellular signaling assays

　　• Mentor graduate students and technicians

　　• Compose manuscripts and postdoctoral fellowships, assist with grant applications

　　Credentials and Qualifications:

　　• PhD in Structural Biology, Molecular Biology, Biophysics, or a related field awarded within the past year (preferred).

　　How to Apply: Interested applicants should email the following to vince.luca@moffitt.org:

　　1) A cover letter that describes their motivation to pursue this position and summarizes past research accomplishments.

　　2) A current CV with recent publications and contact information for three references.