挪威Oslo大学医院执行博士后

　　招聘简介：

　　心血管和肺部疾病科的分子心脏病学研究小组具有3年的公开博士后职位。我们正在寻找具有生物化学，细胞生物学，分子生物学或其他相关专业领域博士学位的候选人。分子心脏病学研究组的主要焦点是揭示心力衰竭的发病机制和进展中的关键分子机制。我们的目标是确定新的干预目标，并根据我们实验室的发明开发新的药物治疗方法。目前主要的努力旨在破解纤维化和细胞衰老在一种通常与高血压，糖尿病和/或肥胖症（舒张性心力衰竭/射血分数保留的心力衰竭）相关的心力衰竭形式的发展中的作用。这一心力衰竭子集占所有诊断为心力衰竭的患者的近50％，并且对当前的治疗方案反应不佳。我们的研究小组是一个由医学博士，生物化学家和分子生物学家组成的多学科团队。我们的团队精通各种技术，包括蛋白质组学和蛋白质结构 - 活性关系研究，心脏中分离的原代细胞的细胞生物学研究，以及基因工程小鼠中疾病模型的研究。

　　义务和责任

　　分子心脏病学小组的研究项目来自于

　　目标蛋白的生物化学结构 - 活性研究，细胞生物学研究，以及基因工程小鼠中适当疾病模型的实验研究。一些正在进行的研究集中于CCN蛋白，这是一种基质细胞蛋白/生长因子家族，已被证明与组织修复机制和纤维化有关。我们最近发现这些蛋白质作为前原蛋白分泌，其需要在从细胞分泌后进行蛋白水解加工以变得具有生物活性（Kaasboll，OJ等人J Biol Chem 293（46）：17953-17970,2018）。

　　英文原文：

　　The Molecular Cardiology Research Group at Division for Cardiovascular and Pulmonary Diseases has an open 3-year postdoctoral position. We are seeking a candidate with PhD-degree in biochemistry, cell biology, molecular biology, or other relevant field of expertise. The major focus of Research Group of Molecular Cardiology is to unravel key molecular mechanisms in the pathogenesis and progression of heart failure. Our goal is to identify novel targets of intervention and to develop novel pharmacologic therapies based on inventions done in our laboratory. Major efforts are currently aimed at deciphering the role of fibrosis and cellular ageing in development of a form of heart failure often associated with high blood pressure, diabetes and/or obesity (diastolic heart failure/ heart failure with preserved ejection fraction). This subset of heart failure accounts for nearly 50% of all patients diagnosed with heart failure and responds poorly to current treatment regimens. Our research group is a multidisciplinary team of medical doctors, biochemists, and molecular biologists. Our team is proficient in a wide range of technologies from proteomics and studies of protein structure-activity relationships, cell biologic studies of isolated primary cells from the heart, and studies of disease models in genetically engineered mice.

　　Duties and responsibilities

　　The research projects of the Molecular Cardiology Group spans from

　　biochemical structure-activity studies of target proteins, cell biologic studies, to experimental studies in appropriate disease models in genetically engineered mice. Several ongoing studies focus on CCN proteins, a family of matricellular proteins/growth factors that has been shown to be involved in tissue repair mechanisms and fibrosis. We have recently uncovered that these proteins are secreted as preproproteins that requires proteolytic processing following secretion from cells in order to become biologically active (Kaasboll, OJ et al J Biol Chem 293(46):17953-17970, 2018).

　　The postdoctoral candidate may either be engaged in biochemical and cell biologic studies of CCN proteins in order to uncover their mechanisms of activation, signal transduction mechanisms and cell biologic functions, or the candidate may work with genetically engineered mice and disease models in order to unravel the role of CCN proteins in cardiac repair mechanisms and fibrosis. Our research group also has ongoing commercialization projects and close collaboration with the Technology Transfer Office of Oslo University Hospital/University of Oslo.

　　Qualifications

　　Formal qualifications: Recent PhD degree (within last 5 years) in relevant area.

　　Excellent oral and written presentation skills are required. Ability to work independently is essential. The application must include a letter of motivation for the position, CV

　　including list of publications, names and contract addresses of 3 references, as well relevant certificates/diplomas. For more information, please contact

　　Professor Håvard Attramadal at e-mail provided below or at 47-90639687.

　　Personal qualities

　　We search for a highly motivated, goal-oriented and hard-working

　　candidate with documented expertise in any of the following areas: protein biochemistry, signal transduction research, cell biology, or integrated physiology studies in genetically engineered mice.

　　We can offer

　　The Institute has state-of-the-art facilities and equipment for

　　gene technology, production and purification of recombinant proteins, as well as for studies of disease models in genetically engineered mice, including high resolution Doppler/echocardiography and molecular imaging of small animals. The research group collaborates with leading international groups and is currently member of Center for Heart Failure Research (www.heartfailure.no), a thematic research area established by Faculty of Medicine, University of Oslo. A career planning program for postdoctoral scientists is offered in collaboration with Oslo University Hospital and University of Oslo.

　　Contacts

　　Håvard Attramadal, Head of Institute/Professor, phone: 0047 906 39 687