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西北大学病毒学/细胞生物学博士后招聘
文章来源:知识人网整理       更新时间:2019年05月17日

  招聘简介:

  病毒学/细胞生物学博士后职位

  在NIH资助的研究项目上有博士后职位,研究微管相关和微管调节蛋白的功能及其在纳格瓦伊病毒感染中的作用。Naghavi博士是芝加哥西北大学Feinberg医学院微生物学免疫学系的副教授。范伯格医学院位于芝加哥市中心。有关Naghavi实验室的更多信息,请访问http://labs.feinberg.westernest.edu/naghavi。/

  我们以前的研究已经确定了HIV-1如何控制微管行为以促进感染,以及宿主因素。这包括微管运动相关的衔接蛋白,以及控制稳定微管丝形成和促进HIV-1感染的特殊微管加末端跟踪蛋白(称为+Tips)。项目将采用一系列分子生物学分析,以及多种固定和活体成像方法,使用超分辨率和共聚焦显微镜来研究HIV-1颗粒如何在感染细胞内移动,包括自然靶细胞类型,如脑内驻留的小胶质细胞和初级巨噬细胞。我们的目标是了解微管、微管动力学调节器和微管运动蛋白如何发挥作用以使HIV-1在核内外移动的分子基础。

  英文原文:

  Postdoctoral position in Virology/Cell Biology

  Postdoctoral positions are available on NIH funded research projects to study the function of microtubule-associated and microtubule regulatory proteins and their role in viral infection in the Naghavi. Dr. Naghavi is an Associate Professor at the Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago. The Feinberg School of Medicine is located in the center of downtown Chicago. Additional information about the Naghavi lab can be found at http://labs.feinberg.northwestern.edu/naghavi/

  Our previous studies have established how HIV-1 controls microtubule behavior to facilitate infection, and the host factors involved. This includes microtubule motor-associated adaptor proteins, as well as specialized microtubule plus-end tracking proteins (called +TIPs) that control the formation of stable microtubule filaments and facilitate HIV-1 infection. Projects will employ a range of molecular biological assays, as well as a variety of fixed and live imaging approaches using super resolution and confocal microscopy to study how HIV-1 particles move within infected cells, including natural target cell types such as brain resident microglia and primary macrophages. Our goal is to understand the molecular basis behind how microtubules, regulators of microtubule dynamics and microtubule motor proteins function to enable HIV-1 movement to and from the nucleus.

  Candidates must have a PhD or equivalent with strong research experience in virology, cell biology and/or molecular biology. Applicants with experience in fluorescence microscopy and live imaging are particularly encouraged to apply. Intersted applicants should submit a complete CV, a brief description of their research achievements and interests, and the name and contact details for three referees to:

  Mojgan.Naghavi@Northwestern.edu

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