美国德州大学安德森癌症中心泌尿内科肿瘤研究部博士后职位招聘

　　招聘简介：

　　泌尿生殖医学肿瘤科博士后研究员（Peter Friedl，医学博士，博士）

　　·德克萨斯大学安德森分校癌症中心

　　·地点：德克萨斯州休斯顿

　　·工作号码：7057149

　　·发布日期：2019年4月29日

　　·申请截止日期：开放至填写

　　职位描述

　　摘要：

　　该职位的重点将是使用小鼠模型和体外测定来理解骨肿瘤中免疫疗法的细胞和分子机制。一名合格的博士后研究员将拥有细胞/肿瘤生物学或免疫学博士学位，有兴趣开发工程环境（如骨微环境）中肿瘤和免疫细胞功能的研究线，并纳入细胞过程的体内成像，包括癌症侵袭（如在骨骼中），癌症免疫细胞相互作用，转移和对治疗的反应。博士后研究员将拥有免疫学和癌症生物学，动物专业知识，荧光显微镜（如落射荧光，共聚焦，多光子 - 所需）的知识，并成为研究团队的积极成员，并与其他主要研究调查人员和初级研究人员合作开展体内和体外研究项目的技术方面。

　　英文原文：

　　Postdoctoral Fellow, Dept of Genitourinary Medical Oncology - Research (Peter Friedl, MD, Ph.D)

　　·         The University of Texas M. D. Anderson Cancer Center

　　·         Location: Houston, TX

　　·         Job Number: 7057149

　　·         Posting Date: Apr 29, 2019

　　·         Application Deadline: Open Until Filled

　　Job Description

　　SUMMARY:

　　The focus of the position will be to understand the cellular and molecular mechanisms of immunotherapy in bone tumors using mouse models and in vitro assays. A qualified postdoctoral fellow will have a PhD in cell/tumor biology or immunology with interest in developing a research line on tumor and immune cell function in engineered environments (e.g. the bone microenvironment) and incorporate in vivo imaging of cellular processes including cancer invasion (e.g. in bone), cancer-immune cell interactions, metastasis and response to therapy. The postdoctoral fellow will possess knowledge of immunology and cancer biology, animal expertise, fluorescence microscopy (e.g. epifluorescence, confocal, multiphoton-desired) and be an active member of the research team and collaborate with other lead research investigators and the Primary Investigator in carrying out technical aspects of in vivo and in vitro research projects.

　　KEY FUNCTIONS:

　　Requires expertise in mouse handling and disease models in small animals, flow cytometry, and work with cell/tissue culture.

　　1. Exercises considerable imagination, initiative, and inventiveness in planning and executing the details of experiments, and in evaluating and interpreting the results both independently and with research team members and PI.

　　Have immunology and cancer biology background and experience in molecular biology and protein biochemistry techniques for cell and tissue samples including immunostainings and microscopy as well as molecular cell analyses. Supports in vitro cell experiments and in vivo animal experiments of tumor cells (e.g. prostate and other) and immune cells. Isolates immune cells from mouse spleen; generates genetically modified cell lines by transfection of fluorescent reporters; maintains cell models by phenotyping (flow cytometry) and FACS sorting; performs immunofluorescence and histology analysis of tissue samples. Based on interest development of the position towards intravital microscopy, tumor microdissection, cell isolation from tumors and molecular profiling is possible.

　　Knowledge in the following procedures are required:

　　• Microscopy (confocal and/or epifluorescence; optional experience with multiphoton imaging)

　　• Animal handling, e.g. breeding, surgery, injection (treatment and tumor implantation) and tissue/organ isolation

　　• Flow cytometry (FACS) and analysis

　　• Immunofluorescence staining of tissue samples

　　• Cell/tissue culture and cryostorage

　　• Histological procedures (e.g. fixation, slicing, staining, sample storage) and Immunohistochemistry

　　• Optional: Protein biochemistry (immunoblotting, co-immunoprecipitation, protein purification)

　　2. Communicate information:

　　• Must be able to communicate results to and understand instructions from the supervisor and principal investigator.

　　• Clear and accurate communication in English both face-to-face and over the telephone/skype is required.

　　• A willingness to cooperate with other staff, students, fellows and visitors is essential.

　　3. Acquire and develop new techniques:

　　• Must be able to learn and/or establish novel techniques and protocols for new research lines; provide progress reports in an organized, consistent manner, review current and relevant scientific literature for project(s)

　　4. Laboratory training and management:

　　• Supervise and train research assistants, students, fellows and/or visitors

　　• Assist in lab managing lab records and inventories (recording per computer)

　　• Assists in ordering of material for the laboratory

　　• Assist in animal and colony maintenance and records

　　• Must work with other lab members to ensure the consistent flow of work, necessary materials and reagents

　　5. Computer literacy:

　　• Must be able to learn and use software related to data acquisition, image analysis and presentation

　　M. D. Anderson Cancer Center is an equal opportunity employer and does not discriminate on basis of race, color, national origin, gender, sexual orientation, age, religion, disability or veteran status except where such distinction is required by law. All positions at The University of Texas M. D. Anderson Cancer Center are security sensitive and subject to examination of criminal history record information. Smoke-free and drug-free environment.

　　Contact Information:

　　Michael Weiger

　　mweiger@mdanderson.org

　　United States

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