美国华盛顿大学癌症生物学、信号转导、基因组学、免疫学方向博士后招聘

　　招聘简介：

　　在密苏里州圣路易斯市华盛顿大学医学院的斯蒂芬·欧博士的实验室里，可以找到一个博士后职位。

　　我们的首要目标是破译驱动血液学恶性肿瘤发生、发展和进展的基本机制。我们研究骨髓增生性肿瘤（MPN），这是一种克隆性疾病，典型的遗传改变激活JAK-STAT信号。我们利用创新的单细胞技术，包括大规模细胞术（cytof）来询问MPN中失调的细胞因子信号网络。潜在的项目也可能利用最近获得的超离子成像系统，将高维单细胞分析与空间定位结合起来。

　　我们利用人类患者样本和小鼠模型来询问MPN发病机制中改变的信号通路。实验室的一个重要研究领域是利用遗传模型来了解炎症细胞因子信号在多发性硬化症中的作用。第二个感兴趣的领域是下一代测序技术的应用，以描述MPN的基因组复杂性和克隆进化。我们还利用病人源性ipscs和crispr位点定向基因编辑来模拟人类mpn发病机制。长期目标是整合这些方法，使表型与潜在基因型相联系。最后，我们试图将这项工作转化为改进的治疗MPN患者。

　　鼓励对癌症生物学、信号转导、基因组学、免疫学、造血、白血病和/或干细胞感兴趣的申请人申请。

　　英文原文：

　　A postdoctoral position is available in the laboratory of Dr. Stephen Oh at Washington University School of Medicine in St. Louis, MO.

　　Our overarching objective is to decipher fundamental mechanisms that drive the initiation, development, and progression of hematologic malignancies. We study myeloproliferative neoplasms (MPNs), which are clonal disorders typified by genetic alterations that activate JAK-STAT signaling.  We utilize innovative single cell technologies including mass cytometry (CyTOF) to interrogate dysregulated cytokine signaling networks in MPNs. Potential projects may also utilize a recently acquired Hyperion Imaging System that couples high dimensional single cell analysis with spatial localization.

　　We utilize human patient samples as well as mouse models to interrogate altered signaling pathways in MPN pathogenesis. A major area of interest in the lab is to utilize genetic models to understand the role of inflammatory cytokine signaling in MPNs. A second area of interest is the application of next generation sequencing technologies to delineate genomic complexity and clonal evolution in MPNs. We also utilize patient-derived iPSCs and CRISPR site-directed gene editing to model human MPN pathogenesis. The long-term objective is to integrate these approaches so that phenotype can be connected to underlying genotype. Ultimately, we seek to translate this work into improved therapies for MPN patients.

　　Applicants interested in cancer biology, signal transduction, genomics, immunology, hematopoiesis, leukemia, and/or stem cells are encouraged to apply.

　　Please see the following links for additional information:

　　http://www.ohlab.org

　　http://hematology.wustl.edu/people/faculty/Oh/Oh_Bio.html

　　Funding through a NIH T32 training grant is available for eligible candidates.

　　Qualifications:

　　Applicants must have a Ph.D. and/or M.D. degree and a strong background in cell and molecular biology. Prior experience with flow cytometry, bioinformatics, genomics, and/or mouse models is highly desirable. Strong written and verbal communications skills are essential.

　　Materials:

　　Please send an inquiry and C.V. with list of references to Dr. Oh at stoh@wustl.edu.

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