马萨诸塞州总医院和哈佛医学院药物化学和化学/分子生物学博士后招聘

　　招聘简介：

　　发现/药物化学和化学/分子生物学的博士后研究金

　　一些博士后奖学金可在OTT实验室获得（http://www.massgeneral.org/research/researchlab.aspx？）ID=1768）位于美国马萨诸塞州波士顿哈佛医学院马萨诸塞总医院癌症研究中心。我们是一个由专门的科学家组成的团队，他们利用计算生物学、化学和功能遗传学的学科来为癌症定义新的基因调控目标。具体来说，我们有兴趣开发早期化学探针，以针对淋巴恶性肿瘤（急性白血病、淋巴瘤、骨髓瘤）中的必需染色质调节剂。

　　英文原文：

　　Post-doctoral fellowships in discovery/medicinal chemistry and chemical/molecular biology

　　Several post-doctoral fellowships are available in the Ott Laboratory (http://www.massgeneral.org/research/researchlab.aspx?id=1768) at the Center for Cancer Research, Massachusetts General Hospital, Harvard Medical School – Boston, MA, United States. We are a team of dedicated scientists that use the disciplines of computational biology, chemistry, and functional genetics to define novel gene regulatory targets for cancer. Specifically, we are interested in developing early-stage chemical probes to target essential chromatin modulators in lymphoid malignancies (acute leukemia, lymphoma, myeloma).

　　Position 1: Discovery/medicinal chemistry of essential gene regulatory factors in cancer

　　The lab is recruiting a post-doctoral synthetic organic chemist with significant experience in small molecule chemistry, and a keen understanding of the principles of medicinal chemistry and translational pharmacology. The ideal candidate will also have a basic understanding of cellular and molecular biology. Available projects include synthesis of chemical probes targeting lysine acetylation pathways, transcription factor ligand development, and deployment of next-generation pharmacologic strategies including targeted protein degradation and covalent probe synthesis. Candidate(s) will have a Ph.D. in organic chemistry, medicinal chemistry, or related discipline.

　　Position 2: Chemical/molecular biology of essential gene regulatory factors in cancer

　　The lab is recruiting a post-doctoral molecular or chemical biologist with a significant interest in using functional and chemical genetics to probe the essential gene regulatory factors of lymphoid malignancies. The ideal candidate(s) will have a Ph.D., M.D., or M.D./Ph.D. in molecular biology, pharmacology, oncology, or related discipline. Familiarity with computational tools useful for genomics and epigenomics research is desirable. Available projects in the lab include understanding mechanisms of cancer cell dependency on lineage-defining gene regulatory factors and associated epigenetic machinery, high-throughput assay design and screening for novel chemical probes, functional genetic screening with gene editing technology to identify new therapeutic targets, and genome-wide chromatin structure analysis to understand gene regulatory malfunction in lymphoid malignancies.

　　Both positions require a high level of self-motivation, excellent communication skills, and the ability to work diligently and cooperatively with others. Successful applicants will be able to work independently, maintain high standards of laboratory safety, and display the intellectual curiosity required to effectively lead multidisciplinary projects.

　　Interested candidates should send a cover letter, CV, and the contact details of three references directly to:

　　Christopher Ott, PhD

　　christopher.ott@mgh.harvard.edu

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