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美国堪萨斯州立大学分子生物学/免疫学/疫苗学博士后招聘
文章来源:知识人网整理       更新时间:2019年04月19日

  招聘简介:

  ·堪萨斯州立大学兽医学院

  ·地点:堪萨斯州曼哈顿

  ·工作编号:7057030

  ·入账日期:2019年4月17日

  ·申请截止日期:开放至填写

  职位描述

  兽医学院的诊断医学/病理学系正在申请研究员(博士后)。博士后研究员将负责对非洲猪瘟病毒保护性抗原的鉴定、原型疫苗的制备以及对猪进行疗效研究。其他的研究领域将涉及定义新的保护性bvdv表位,测试牛体内新bvdv镶嵌抗原的疗效和交叉保护。一些工作还将针对横向流诊断工具的开发/优化以及市场上没有商业产品的感兴趣的elispot读数。正在进行的美国农业部和国家卫生研究院支持的研究项目将利用多个活载体平台,并将在商业猪和牛的BSL2/3水平进行研究。

  英文原文:

  ·         Kansas State University College of Veterinary Medicine

  ·         Location: Manhattan, KS

  ·         Job Number: 7057030

  ·         Posting Date: Apr 17, 2019

  ·         Application Deadline: Open Until Filled

  Job Description

  The Department of Diagnostic Medicine/Pathobiology within the College of Veterinary Medicine is seeking applicants for a Fellow (Post Doc). The postdoctoral fellow will be responsible for conducting ongoing research in identification of protective African Swine Fever Virus antigens, formulation of prototype vaccines, and conducting efficacy studies in pigs. Additional area of research will involve defining novel protective BVDV epitopes, testing efficacy and cross-protection of novel BVDV mosaic antigens in cattle. Some efforts will also be directed at the development/optimization of Lateral Flow diagnostic tools and EliSpot readouts of interest for which there is no commercial products in the market. The on-going USDA and NIH supported research projects will utilize multiple live vector platforms, and studies will be conducted in commercial swine and cattle at BSL2/3 levels.

  Responsibilities include:

  -Define correlates of immune protection against livestock [African Swine Fever Virus and Bovine Viral Diarrhea Virus] and human pathogens of interest.

  -Utilize the correlate of protection knowledge, and cutting edge technology and approaches to rationally identify protective vaccine targets.

  -Design, generate, quality control validate recombinant live-vectored/protein-based prototype vaccines.

  -Conduct prototype vaccine safety, tolerability, and immunogenicity studies in relevant hosts. The in vivo studies will evaluate multiple adjuvant-antigen combinations in dose escalation/dose limiting studies.

  -Evaluate protective efficacy of lead prototype immunogen formulations in relevant hosts

  -Participate in planning experiments.

  -Data analysis and interpretation.

  -Generate technical reports and manuscripts.

  -Participate in research proposal development

  -Submit intramural and extramural grant proposals

  -Hands-on training of new students and provide oversight of daily programmatic activities.

  -Function as the lab manager and ensure compliance with university regulations

  -Develop lateral flow-based diagnostic tools

  -Develop and optimize EliSpot/Flow assay-based cytotoxic T lymphocyte [CTL] readout for swine and cattle.

  Required Qualifications:

  -Ph.D. training in Molecular biology/Immunology/Vaccinology

  -Hands-on experience generating live-vectored subunit vaccines

  -Generation and affinity purification of recombinant proteins using mammalian cells/insect cells/yeast

  -Conducting safety/immunogenicity and experimental vaccine efficacy studies in cattle and pigs

  -Hands-on experience conducting cytotoxic T lymphocyte killing assays using chromium-release assay or other assays

  -Conducting EliSpot assays using cattle and pig lymphocytes

  Preferred Qualifications:

  -Experience with analysis and interpretation of vaccine response data from swine and cattle

  -Proposal development

  -Development of lateral flow assay and adjuvants

  -Hands-on skills in generating and maintaining primary swine and bovine fibroblasts

  -Skills in bioinformatics and FACS

  -Excellent oral and written communication skills

  To apply, please go to www.ksu.edu/jobs requisition #506976

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