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美国治亚州乔治亚理工大学达尔曼实验室博士后职位
文章来源:知识人网整理       更新时间:2019年04月15日

  招聘简介:

  需要:一个结合病毒基因治疗和DNA条形码纳米粒的博士后

  佐治亚理工学院和埃默里医学院的达尔曼实验室(dahlman lab.org)开创性地将DNA条形码纳米粒子用于sirna、mrna和cas9疗法。我们第一次可以评估数千种不同的纳米颗粒如何在动物体内传递RNA和DNA药物,而不是在细胞培养中评估它们。自2016年成立全新实验室以来,已在JACS、PNAS、Advanced Materials、ACS Nano等期刊上发表了8篇DNA条形码/基因编辑/基因治疗论文。目前,该实验室已发展到约15人,细胞、Nano自然、美国科学院等机构正在审查论文。在过去的2.5年中,实验室已经生成了数十万个体内基因治疗数据点;这种数据生成规模对于纳米医学来说是新的。例如,下面的heatmap描述了单个实验产生的大约8000个体内药物传递数据点。利用生物信息学管道,这些数据被用于开发新的CAS9疗法。

  英文原文:

  Needed: A post-doc to combine viral gene therapy with DNA barcoded nanoparticles

  The Dahlman Lab at Georgia Tech and Emory School of Medicine (dahlmanlab.org) is pioneering the use of DNA barcoded nanoparticles for siRNA, mRNA, and Cas9 therapies. For the first time, we can evaluate how thousands of different nanoparticles deliver RNA and DNA drugs in animals, instead of evaluating them in cell culture. Since starting as a brand-new lab in 2016, 8 DNA barcoding / gene editing / gene therapy papers in JACS, PNAS, Advanced Materials, ACS Nano, and other journals have been published. With the lab now having grown to ~15 people, papers are currently under review at Cell, Nature Nano, Scientific American, and others. In the last 2.5 years, the lab has generated hundreds of thousands of in vivo gene therapy data points; this scale of data generation is new to nanomedicine. For example, the heatmap below depicts ~8,000 in vivo drug delivery data points generated from a single experiment. Using bioinformatics pipelines, these data are used to develop new Cas9 therapies.

  We are hiring a post-doc with a background in capsid shuffling and AAV libraries. This post-doc will work on a brand new, highly translational, project. The first goal will be to quickly generate several high-quality publications. Training will be provided in efficient experimental design, aimed at maximum publishable data generation/unit of effort. Most recently, a former Ph.D. student in the lab published and submitted 14 papers (PNAS, JACS, etc.) in their first 2.5 years. Furthermore, this position will provide experience in Biotechnology startup creation and developing relationships with leading industry partners interested in translating projects to direct clinical applications.

  This is a unique opportunity. First, you will be a member of an exciting, diverse, and interdisciplinary group. Second, you will learn about nanoparticle DNA barcoding, which combines high throughput chemistry, nanoparticle characterization, RNA therapies, Cas9, and genomics. Third, you will be working in a cutting-edge field (gene therapies). Finally, the Georgia Tech and Emory Medical School Department of Biomedical Engineering is ranked #3 and #2 for undergraduate and graduate studies, respectively. Located in Atlanta, a thriving city with major cultural, professional, and athletic institutions, the standard salary goes much farther here than in New York, Boston, and San Francisco. Nicknamed the ‘city in a forest,’ Atlanta offers great food, music, breweries, hiking, biking, weather, and other attractions. Finally, the Dahlman Lab is a supportive and inclusive environment; we care deeply about all our lab members, independent of their background, experiences, preferences, or beliefs.

  Email a CV to james.dahlman@bme.gatech.edu.* Due to the time sensitivity of this project, applicants for the position will be evaluated in the order applications are received.*

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