美国宾西法尼亚大学医学院分子生物学、生物化学、细胞生物学、癌症、神经科学等方向博士后招聘

　　招聘简介：

　　宾夕法尼亚大学佩雷尔曼医学院杨晓鲁博士的实验室有两个博士后职位。实验室研究神经退行性疾病和癌症。目前的项目主要集中在两个方面：

　　（1）蛋白质质量控制与神经退行性疾病的发病机制。我们的实验室最近在动物细胞中发现了一种新的蛋白质质量控制系统，它具有多功能和强大的功能。我们正在研究这个系统的作用机制及其在老年和神经退行性疾病（包括阿尔茨海默病、帕金森病、ALS和多谷氨酰胺疾病）中的作用。

　　（2）肿瘤抑制因子p53和肿瘤细胞代谢。我们对卓越的肿瘤抑制因子p53的功能和调控很感兴趣。我们最近的研究结果显示p53在调节代谢中起着重要作用。我们正在继续研究p53作为各种代谢活动的前哨和调节器的功能。我们也在研究促进肿瘤发生和发展的代谢变化。

　　英文原文：

　　Two postdoctoral positions are available in the laboratory of Dr. Xiaolu Yang at the Perelman School of Medicine at the University of Pennsylvania. The lab studies neurodegenerative diseases and cancer. Current projects focus on two areas:

　　(1) Protein quality control and the pathogenesis of neurodegenerative diseases. Our lab recently identified a novel protein quality control system in animal cells that is multifunctional and powerful. We are investigating the mechanism of action of this system and its role in aging and neurodegenerative diseases including Alzheimer’s disease, Parkinson’s disease, ALS, and polyglutamine diseases.

　　(2) The tumor suppressor p53 and tumor cell metabolism. We are interested in the functions and regulation of preeminent tumor suppressor p53. Our recent results revealed an important role for p53 in modulating metabolism. We are continuing to investigate the function of p53 as both a sentinel and a regulator for various metabolic activities. We are also studying metabolic alterations that drive tumor initiation and progression.

　　For more information on the laboratory and its research, please see the following publications and website:

　　Nature Communications 9(1): 1223, 2018

　　Nature Communications 9(1): 4683, 2018

　　Cell Reports 18(13): 3143-3154, 2017

　　Molecular Cell 55: 15-30, 2014 (cover article)

　　Nature 493: 689-93, 2013

　　Nature Cell Biology 15: 991-1000, 2013 (cover article)

　　Nature Cell Biology 13: 310-6, 2011 (cover article)

　　Molecular Cell 37: 668-78, 2010 (cover article)

　　Cell 133: 415-26, 2008

　　Molecular Cell, 31: 415-21, 2008

　　http://www.med.upenn.edu/apps/faculty/index.php/g20000320/p20138

　　Successful candidates should have an expected or recently earned Ph.D. degree, a strong record of scientific productivity, and extensive experience in a related field, including but not limited to molecular biology, biochemistry, cell biology, cancer, metabolism, neuroscience, and cell/mouse models of neurodegenerative diseases.

　　To apply, please send a cover letter, curriculum vitae, and the names and addresses of three references to:

　　Xiaolu Yang, PhD

　　Professor, Department of Cancer Biology

　　Investigator, Abramson Family Cancer Research Institute

　　Member, Penn Medicine Neuroscience Center

　　Perelman School of Medicine

　　University of Pennsylvania

　　654 BRB 2/3, 421 Curie Blvd

　　Philadelphia, PA 19104-6160

　　xyang@pennmedicine.upenn.edu