牛津大学CRUK/MRC牛津放射与肿瘤研究所结直肠癌的遗传学、细胞生物学和分化博士后招聘

　　招聘简介：

　　工资：7年级：32236英镑-39609英镑/年。

　　一位博士后研究员有机会加入沃尔特·布默爵士的研究小组，该小组致力于结直肠癌的遗传学、细胞生物学和分化研究，特别关注新型免疫疗法的发展。您的主要职责是开发和执行针对肿瘤决定因素的双特异性单克隆抗体以及与T淋巴细胞结合的表面标志物的临床前测试。这将涉及使用实验室广泛收集的120多个主要具有完全特征的结直肠癌（CRC）衍生细胞系以及从新获得的CRC活检获得的CRC类有机物。你还将在其他项目中帮助控制分化和肌成纤维细胞/上皮细胞相互作用，这些项目由研究生和实验室的访客负责。这将包括为研究小组经验不足的成员提供指导。

　　你将适应现有的，并开发新的，科学的技术和实验方案，并将被期望为新的研究项目开发和贡献想法。

　　英文原文：

　　Salary: Grade 7: £32,236 - £39,609 p.a.

　　An opportunity has arisen for a Postdoctoral Researcher to join Sir Walter Boomer’s research group working on the genetics, cell biology and differentiation of colorectal cancer, with a special interest in the development of novel immunological therapies. Your main role will be to develop and carry out preclinical testing of bispecific monoclonal antibodies targeted against tumour determinants as well as T lymphocyte engaging surface markers. This will involve the use of the laboratory’s extensive collection of more than 120, mostly fully characterised, colorectal cancer (CRC) derived cell lines as well as CRC organoids derived from freshly obtained CRC biopsies. You will also be expected to help in other projects on aspects of the control of differentiation and myofibroblast/epithelial cell interactions being undertaken by graduate students and visitors in the laboratory. This will include providing guidance to less experienced members of the research group.

　　You will adapt existing, and develop new, scientific techniques and experimental protocols and will be expected to develop and contribute ideas for new research projects.

　　You will hold (or be working towards) a relevant PhD/DPhil in biology, molecular biology or a related science and will have a high level of technical competence in standard molecular and cell biological techniques, including especially cell culture and, for example, western blotting, immunofluorescence, transfection, DNA and RNA isolation.

　　This is a full-time post offered for 14 months in the first instance.

　　All applicants must complete a short application form, upload a CV and supporting statement.

　　The closing date for applications is 12.00 noon on 24 April 2019.