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美国匹兹堡大学癌症免疫学/免疫治疗方向博士后招聘
文章来源:知识人网整理       更新时间:2019年03月26日

  招聘简介:

  研究领域:癌症免疫学和免疫疗法

  职位描述:匹兹堡大学外科肿瘤学系外科系立即在Kammula实验室开设一名才华横溢,充满激情的博士后研究员/助理。肿瘤外科的主要目标是开发通过免疫学,病毒学和分子生物学技术治疗癌症的新方法,并将研究结果转化为患者治疗。我们有兴趣为一个专注于过继性T细胞治疗癌症的实验室招募博士或MD /博士候选人。请参阅PMID:28395880; PMID:26712692; PMID:26100671; PMID:25424856,详细的实验室研究兴趣。

  该博士后研究员将致力于开发过继性T细胞免疫治疗晚期癌症的独立和合作项目。成功的申请人将采用克隆T细胞受体的策略和用恶性肿瘤表达的抗原特异性的TCR对人T细胞进行遗传修饰。使用人T细胞和体内鼠模型的体外研究将用于开发和测试新型T细胞疗法。博士后研究员将进行相关研究,以评估抗原特异性T细胞在过继性T细胞免疫治疗的人体临床试验中的转移,持久性和功能。该职位将涉及分子工作,包括PCR,克隆,载体设计,以及细胞培养,流式细胞术,细胞间染色,转染和ELISA / ELISPOT。

  英文原文:

  Research Area: Cancer Immunology and Immunotherapy

  Position Description: The Department of Surgery, Division of Surgical Oncology at the University of Pittsburgh has an immediate opening in the Kammula Lab for a talented and passionate postdoctoral fellow/associate. The Division of Surgical Oncology’s primary goal is to develop novel methods for treating cancers through immunology, virology, and molecular biology techniques, and to translate research findings into patient treatments. We are interested in recruiting PhD or MD/PhD candidates for a laboratory that focuses on adoptive T cell therapies for cancer.  Please see PMID: 28395880; PMID: 26712692; PMID: 26100671; PMID: 25424856 for detailed lab research interest.

  The post-doctoral research fellow will work on independent and collaborative projects developing adoptive T cell immunotherapy for advanced cancers. The successful applicant will employ strategies for cloning T cell receptors and genetic modification of human T cells with TCRs specific for antigens expressed by malignancies. In vitro studies using human T cells and in vivo murine models will be used to develop and test novel T cell therapies. The post-doctoral fellow will perform correlative studies to evaluate the transfer, persistence and function of antigen-specific T cells in human clinical trials of adoptive T cell immunotherapy. The position will involve molecular work with PCR, cloning, vector design, as well as cell culture, flow cytometry, intercellular staining, transfections, andELISA/ELISPOT.

  Candidates that have an interest in mechanistic and translational studies in cancer immunology and immunotherapy are encouraged to apply. The qualified applicants will be required to conduct research, interpret results, prepare manuscripts, and aid in the preparation of grant applications. The required expertise includes all common molecular biology and cellular immunology techniques, molecular cloning, cell culture, and experience with murine in vivo models. The applicant should have command of the English language, good interpersonal skills, critical thinking ability and evidence of experience and good writing skills through first author publications in peer reviewed journals. The applicant should also be proficient in computer software usage including Word, Excel, PowerPoint, and statistical packages.

  To be considered for one of these positions, please provide a one-page statement of research interest, a current curriculum vitae and contact information for three-references to: surgoncapplicants@upmc.edu.

  Employer Name: The University of Pittsburgh

  Position Location: Pittsburgh, PA

  Disclaimers: The University of Pittsburgh offers competitive compensation and benefits packages. “The University of Pittsburgh is an EEO/AA/M/F/Vets/Disabled employer”.

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