美国密歇根大学博士后职位

　　招聘简介：

　　在密歇根大学生命科学研究所的实验室里，积极进取、有组织的个人寻求一个研究员的职位。研究项目旨在通过调节棕色和米色脂肪细胞的适应性热生成，确定可用于治疗肥胖和相关代谢紊乱的靶点。我们最近发现了一种新的米色脂肪激活调控途径（自然医学，2018，24（6）：814-822）。这项研究是由NIH、ADA和许多其他资助机构资助的。申请者拥有不到12个月的学位后工作经验，可以申请两个具有高度声望和竞争力的博士后项目：密歇根生命科学研究生项目（https://lifecifellows.umich.edu）和密歇根博士后先锋项目（https://umichchiproferprogram.org/），这两个项目都提供额外的薪水和财务回报。资料来源，以及研究思路的灵活性和自由度。

　　实验职责包括但不限于：

　　分子生物学、PCR、DNA和RNA纯化、质粒克隆、qpcr基因表达分析和Western blotting。具有永生化细胞系和原代细胞分离和分化的哺乳动物细胞培养。逆转录病毒或腺病毒技术是首选。该研究将涉及基因啮齿动物模型，因此有小鼠遗传学和动物生理学经验者优先。有代谢方面的经验者优先。

　　英文原文：

　　Highly motivated, organized individual sought for a position as a research fellow in a laboratory at the Life Sciences Institute of the University of Michigan. Research Project aims to identify targets that can be exploited therapeutically for the treatment of obesity and associated metabolic disorders, through regulating adaptive thermogenesis in brown and beige adipocytes. We recently identified a novel regulatory pathway for beige fat activation (Nature Medicine, 2018, 24(6): 814-822). The research is funded by grants from NIH, ADA and many other funding agencies. Applicants have less than 12 months post-degree experience may be eligible to apply two highly prestigious and competitive postdoc programs: Michigan Life Science Fellows Programs (https://lifescifellows.umich.edu) and Michigan Postdoctoral Pioneer Program (https://umichpioneerprogram.org/), both of which provide additional salary and financial resources, along with flexibility and freedom to pursue research ideas.

　　Experimental duties will include but are not limited to:

　　Molecular biology, PCR, DNA and RNA purification, plasmid cloning, gene expression analysis by qPCR and western blotting. Mammalian cell culture with both immortalized cell lines and primary cell isolation and differentiation. Retroviral or adenoviral techniques are preferred. The research will involve genetic rodent models, so experience with mouse genetics and animal physiology is preferred. Experience in the metabolic field is preferred.

　　Starting date: ASAP

　　Required Qualifications:

　　Ph.D. in fields related to biomedical sciences, publications in high profile journals as a primary author and three experts in the related fields as references.

　　Please contact: wujunz@umich.edu