冷泉港实验室染色体畸变研究博士后招聘

　　招聘简介:

　　冷泉港的谢尔茨实验室正在为一个研究癌症染色体畸变的资助项目寻找博士后研究人员。

　　大规模基因剂量失衡在人类肿瘤中普遍存在。例如，超过一半的乳腺癌含有染色体臂1q的扩增，使得这种变化在乳腺癌基因组中比TP53、BRCA1和BRCA2突变组合更常见。尽管这些非整倍体的出现频率很高，但人们对它们的出现原因以及它们如何影响肿瘤的进展知之甚少。

　　谢尔茨实验室正在探索新的基于crispr的染色体工程方法，研究基因剂量失衡在肿瘤发生中的作用。通过精确地操纵癌症核型，我们可以发现特定非整倍体的独特后果，而不存在任何其他的基因改变。这些方法揭示了非整倍体可能影响癌症生理学的多种意想不到的方式。我们正在寻找有兴趣使用这些技术的博士后，以揭示染色体畸变和染色体不稳定如何影响癌症的发生、耐药性和转移传播。

　　英文原文：

　　The Sheltzer Lab at Cold Spring Harbor is seeking postdoctoral researchers for a funded project studying chromosomal aberrations in cancer.

　　Large-scale gene dosage imbalances are ubiquitous in human tumors. For instance, more than half of all breast cancers harbor an amplification of chromosome arm 1q, making this alteration more common in breast cancer genomes than mutations TP53, BRCA1, and BRCA2, combined. Despite the frequency of these aneuploidies, little is known about why they arise or how they affect tumor progression.

　　The Sheltzer laboratory is pioneering new CRISPR-based chromosome engineering methods to study the role that gene dosage imbalances play in tumorigenesis. By precisely manipulating cancer karyotypes, we can uncover the unique consequences of specific aneuploidies, absent any other genetic alterations. These approaches have revealed multiple unexpected ways that aneuploidy can affect cancer physiology. We are seeking postdocs who are interested in using these techniques to uncover how chromosomal aberrations and chromosomal instability can influence cancer initiation, drug resistance, and metastatic dissemination.

　　The Sheltzer Lab is a highly-collaborative environment that values rigorous research and that welcomes scientists from all backgrounds. We are located at Cold Spring Harbor Laboratory, an immersive research institute on the outskirts of New York City. Cold Spring Harbor is an NCI-designated Cancer Center, and every year over 10,000 scientists journey to Cold Spring Harbor to attend one of CSHL’s renowned Meetings and Courses.

　　More information on research conducted in the Sheltzer Lab can be found on our website at www.sheltzerlab.org.

　　CSHL is an EO/AA Employer. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability or protected veteran status.

　　Interested candidates should send a cover letter and CV to sheltzer@cshl.edu. Please also apply for this this position via the CSHL website at: http://cshl.peopleadmin.com/postings/14705