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英国剑桥欧洲分子生物学实验室博士后职位
文章来源:知识人网整理       更新时间:2019年03月18日

  招聘简介:

  关于团队/工作

  我们正在招募两位核心博士后研究员,分别在进化系统生物学、基于蛋白质组学的磷酸化/泛素信号或基因型到表型分析领域担任研究员。

  我们的研究小组通常有兴趣研究遗传变异是如何通过细胞生物学的变化引起表型差异的。在这一宽泛的范围内,我们有一系列的研究集中于整合不同的变异效应预测因子(www.mutfunc.com),Wagih等人Mol Sys Bio 2018),以解释基因型和表型之间的分子后果(Galardini等人ELIFE 2017)。

  该组的第二个研究领域是我们对磷酸化信号的研究的主要兴趣,我们利用磷蛋白组学数据来研究:磷酸化的进化和功能相关性(Studer等人Science 2016,Ochoa等人Biorxiv 2019),全球激酶信号系统和特异性,(Ochoa等人Mol Sys Bio 2016;Bradley等人Biorxiv 2018)和疾病中激酶信号的变化(Memon等人BioxIV 2019)。我们也有兴趣将这些相同的观点应用于泛素调节的研究。最后,我们对癌症基因组学越来越感兴趣(Gon_alves等人通过与DEPMAP联盟(http://depmap.org/sanger)的合作,了解癌症细胞株中基因缺失反应和药物反应的差异。

  英文原文:

  About the team/job

  We are recruiting for 2 core funded Postdoctoral Fellow positions in broad areas of evolutionary systems biology; proteomic based study of phosphorylation/ubiquitin signalling or genotype-to-phenotype analysis.

  Our group is generally interested in studying how genetic variation gives rise to phenotypic differences via changes in the biology of the cell. Within this broad scope, we have a line of research focused on integrating different variant effect predictors (www.mutfunc.com), Wagih et al. Mol Sys Bio 2018) in order to interpret the molecular consequences that are intermediate between genotype and phenotype (Galardini et al. eLife 2017).

  A second area of study in the group is our major interest in the study of phosphorylation signalling, where we make use of phosphoproteomic data to study: the evolution and functional relevance of phosphorylation (Studer et al. Science 2016, Ochoa et al. bioRxiv 2019), global kinase signalling systems and specificity, (Ochoa et al. Mol Sys Bio 2016; Bradley et al. bioRxiv 2018) and changes in kinase signalling in disease (Memon et al. bioRxiv 2019). We are also interested in applying several of these same ideas to the study of ubiquitin regulation. Finally, we have a growing interest in cancer genomics (Gonçalves et al. Cell Systems 2017) and understanding differences in gene deletion responses and drug responses in cancer cell lines, through collaboration with the DepMap consortium (http://depmap.org/sanger).

  Your role

  We welcome applicants with a PhD and an interest in contributing to any of the areas of research in the group (https://www.ebi.ac.uk/beltrao). We are primarily looking for applicants a very strong bioinformatics background but we will consider also candidates that are interested in combining experimental work with computational analysis.

  You have

  Considered applicants must hold a PhD in Life Sciences with experience in computational biology. We welcome applicants from diverse starting backgrounds in computational biology. Examples of backgrounds that could fit the group would be those with experience in: computational analysis of proteomics data; structural bioinformatics, drug target prediction and chemical-informatics; association genetics; evolution of regulatory elements; ancestral sequence/state reconstructions; and cancer genomics.

  The post holder should enjoy working in a highly collaborative and interdisciplinary environment. Good written and oral communication skills are essential.

  Informal enquiries about the post can be directed to pbeltrao@ebi.ac.uk

  Why join us

  At EMBL-EBI, we help scientists realise the potential of ‘big data’ in biology by enabling them to exploit complex information to make discoveries that benefit mankind. Working for EMBL-EBI gives you an opportunity to apply your skills and energy for the greater good. As part of the European Molecular Biology Laboratory (EMBL), we are a non-profit, intergovernmental organisation funded by 22 member states and two associate member states. We are located on the Wellcome Genome Campus near Cambridge in the UK, and our 600 staff are engineers, technicians, scientists and other professionals from all over the world.

  EMBL is an inclusive, equal opportunity employer offering attractive conditions and benefits appropriate to an international research organisation. The remuneration package comprises a competitive salary, a comprehensive pension scheme and health insurance, educational and other family related benefits where applicable, as well as financial support for relocation and installation. For more information about pay and benefits click here

  We have an informal culture, international working environment and excellent professional development opportunities but one of the really amazing things about us is the concentration of technical and scientific expertise – something you probably won’t find anywhere else.

  If you’ve ever visited the campus you’ll have experienced first-hand our friendly, collegial and supportive atmosphere, set in the beautiful Cambridgeshire countryside. Our staff also enjoy excellent sports facilities including a gym, a free shuttle bus, an on-site nursery, cafés and restaurant and a library.

  What else do I need to know

  To view a copy of the full job description please click here

  To apply please submit a covering letter and CV through our online system.

  Applications are welcome from all nationalities and this will continue after Brexit. For more information please see our website. Visa information will be discussed in more depth with applicants selected for interview.

  EMBL-EBI is committed to achieving gender balance and strongly encourages applications from women, who are currently under-represented at all levels. Appointment will be based on merit alone.

  Applications will close at 23:00 GMT on the date listed above.

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