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德国癌症研究中心博士后职位
文章来源:知识人网整理       更新时间:2019年03月18日

  招聘简介:

  德国癌症研究中心是德国最大的生物医学研究机构。我们拥有约3000名员工,在癌症研究领域开展了广泛的科学项目。

  信号转导和生长控制的划分正在寻求博士后(参考号:2019-0063)

  多形性胶质母细胞瘤四级(GB)是人类最常见、最恶性的原发性脑肿瘤,其特点是增殖率高、侵袭性强、预后极差。尽管在这一领域进行了广泛的研究,但标准的治疗护理,包括最大限度的手术切除(如适用),加上放射治疗和化疗,多年来一直保持不变,等待着新的、更具针对性和更有效的治疗方法的发展。

  我们的部门有兴趣了解胶质瘤细胞侵袭的分子机制,这是导致胶质母细胞瘤复发并最终导致患者死亡的主要原因之一。本课题旨在研究肿瘤微环境(TME)细胞与胶质瘤细胞之间的相互作用,以确定促进胶质瘤细胞侵袭的新分子途径。为此,我们优化了基于器官型脑切片培养(Eisemann et al.,2018,BMC Cancer 18:103)的体外侵入检测,该方法允许操纵肿瘤细胞和微环境,从而在可靠的背景下研究细胞迁移的速率限制因素。

  英文原文:

     The German Cancer Research Center is the largest biomedical research institution in Germany. With approximately 3,000 employees, we operate an extensive scientific program in the field of cancer research.

  The Division of Signal Transduction and Growth Control is seeking a

  Postdoc

  (Ref-No. 2019-0063)

  Glioblastoma multiforme WHO grade IV (GB) is the most common and most malignant primary brain tumor in humans characterized by a high proliferative rate, aggressive invasiveness and a very poor prognosis. Despite an extensive research in the field the standard care of treatment, consisting in maximal surgical resection when applicable, together with radio- and chemotherapy, has been unchanged for many years and awaits the development of novel, more targeted and effective therapies.

  Our division is interested in understanding molecular mechanism underlying glioma cell invasion, which is one of the main causes of glioblastoma recurrence that eventually leads to patients death. The current project aims at investigating the cross-talk between cells of the tumor microenvironment (TME) and glioma cells in order to identify novel molecular pathways promoting glioma cell invasion. To this aim we optimized an ex vivo invasion assay based on organotypic brain slice culture (Eisemann et al., 2018, BMC Cancer 18:103), which allows manipulation of tumor cells as well as the microenvironment, permitting the investigation of rate limiting factors of cell migration in a reliable context.

  Description:

  The candidate will apply gain-of-function and loss-of-function approaches to define the role of candidate genes in tumor cell migration and invasion using state-of-the-art transgenic and CRISPR / gRNA knock-out technologies in glioma cell lines and tumor neurospheres inoculated into murine organotypic brain slices. These in vitro approaches will be complemented by in vivo studies based on orthotopic implantation of syngeneic glioma cell lines in mice. These cells newly generated in our laboratory, which we recently used to investigate the role of the transmembrane glycoprotein podoplanin in glioma progression (Eisemann et al., 2018, Neuro Oncol) constitute a highly valuable tool to study not only glioma cell invasion but different aspects of glioma cell biology.

  The candidate will characterize the different newly syngeneic glioma cell lines via analysis of RNA and DNA sequencing combined with immunostaining of orthotopic gliomas and employ this preclinical mouse model to study the impact of the tumor microenvironment in brain tumor progression and therapy resistance.

  Your profile:

  We are looking for a highly motivated and ambitious postdoc with a master in the field of biology (or comparable degree) and a Ph.D. to complement our team. The candidate should have a strong background in molecular and cellular biology demonstrated by peer-reviewed publications and a strong interest in brain tumor biology. Excellent experimental and analytical skills in advanced cell culture techniques and mouse genetics including animal experimentation are mandatory. Familiarity with stereotactic device for brain cell implantation and experience with multi-omics datasets are a plus.

  The position is limited to 2 years with the possibility of prolongation.

  The position can in principle be part-time.

  For further information please contact Prof. Dr. Peter Angel, phone +49 6221 42-4570.

  The German Cancer Research Center is committed to increase the percentage of female scientists and encourages female applicants to apply. Among candidates of equal aptitude and qualifications, a person with disabilities will be given preference. To apply for a position please use our online application portal (">www.dkfz.de)*.

  We ask for your understanding that we cannot return application documents that are sent to us by post (Deutsches Krebsforschungszentrum, Personalabteilung, Im Neuenheimer Feld 280, 69120 Heidelberg) and that we do not accept applications submitted via email. We apologize for any inconvenience this may cause.

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