加拿大阿尔伯塔大学分子神经退行性疾病研究博士后职位招聘

　　招聘简介：

　　分子神经退行性变博士后研究员

　　·阿尔伯塔大学

　　·地点：加拿大埃德蒙顿

　　·工作编号：7056447

　　·入账日期：2019年3月13日

　　·申请截止日期：开放至填写

　　职位描述

　　我们寻求一位才华横溢、充满激情的科学家加入Westaway实验室（https://www.ualberta.ca/faculties/centersinstitutes/prion centre）。Westaway博士的研究小组有兴趣了解神经疾病的发生和传播的分子机制，包括额颞叶痴呆、迟发性阿尔茨海默病和散发性CJD。

　　这个特定项目的目的是确定肠道微生物群及其代谢物在转基因小鼠额颞叶痴呆发展中的作用。该项目将涉及微生物种群及其代谢产物的分析、脑组织的分析以及细胞培养模式的研究。应试者应具有最近获得的相关分子、神经科学和生化经验的博士学位。需要在组织培养、mRNAs和蛋白质的基因表达分析、核磁共振波谱和动物手术方面具有重要的专业知识。在动物行为测试方面的经验也将是有利的。

　　成功的候选人将有很强的实验技能和研究成果的重要记录。他们将有能力以坚韧和最高质量标准开展独立的创新研究。良好的组织、记录和英语沟通能力（书面和口头）是必需的。我们提供有竞争力的薪酬和福利，提供最先进的基础设施和设备，以及高度互动、刺激和国际化的工作环境。该职位将尽快开始，最初的任期为一年。

　　英文原文：

　　Postdoctoral fellow in Molecular Neurodegeneration

　　·         University of Alberta

　　·         Location: Edmonton, Canada

　　·         Job Number: 7056447

　　·         Posting Date: Mar 13, 2019

　　·         Application Deadline: Open Until Filled

　　Job Description

　　We seek a talented and passionate scientist to join the Westaway lab (https://www.ualberta.ca/faculties/centresinstitutes/prion-centre). Dr. Westaway’s group is interested in understanding the molecular mechanisms of initiation and spreading of neurological diseases including frontotemporal lobar dementia, late-onset Alzheimer’s Disease and sporadic CJD.

　　The aim of this specific project is to determine the role of gut microbiota and their metabolites in the development of frontotemporal lobar dementia in a transgenic mouse model. This project will involve analysis of microbial populations and their metabolites, analysis of brain tissue and work with cell culture paradigms. Candidates should have a recently obtained PhD with relevant molecular, neuroscience and biochemical experience. Significant expertise in tissue culture, gene expression analysis for mRNAs and protein, NMR spectroscopy and animal surgery is required. Experience in animal behavioral testing would also be advantageous.

　　The successful candidate will be expected to have strong experimental skills as well as a significant track record of research accomplishments. They will have the ability to carry out independent creative research with tenacity and to the highest quality standards. Excellent organizational, record-keeping and English communication skills (both written and spoken) are required. We offer competitive salary and benefits, access to state-of-the art infrastructure and equipment and a highly interactive, stimulating and international work environment. The position will commence as soon as possible with an initial appointment for a one-year term.

　　Interested candidate should send by email: a statement of interest, a curriculum vitae, PDF files for the papers in which you are first or co-first author, and contact to:

　　Dr. Nathalie Daude

　　Email: daude@ualberta.ca

　　Keyword: dementia, fluorescence microscopy, genomics, Alzheimer, gene expression