美国桑福德·伯纳姆医学研究所表观遗传学方向博士后职位招聘

　　招聘简介：

　　单细胞水平的三维表观遗传学景观——博士后助理

　　Sanford Burnham Prebys医学发现研究所（SBP）博士后

　　该职位可在加利福尼亚州拉荷亚的桑福德·伯恩汉姆·普雷比斯医学发现研究所Alexey Terskikh的实验室获得，该实验室是一个发展、衰老和再生项目。SBP是一个卓越的、独立的生物医学研究机构，致力于了解人类生物学和疾病，推动科学发现对人类健康产生深远影响。40多年来，我们的研究在癌症、神经科学、免疫学和儿童疾病方面取得了突破性进展，并由NCI指定的癌症中心和先进的药物发现能力所支撑。

　　英文原文：

　　3D epigenetic landscape at single cell level – Postdoctoral Associate

　　Sanford Burnham Prebys Medical Discovery Institute (SBP)A postdoctoral

　　position is available in the laboratory of Alexey Terskikh, Development, Aging,and Regeneration Program, Sanford Burnham Prebys Medical Discovery Institute,La Jolla, California. SBP is a preeminent, independent biomedical research institute dedicated to understanding human biology and disease and advancing scientific discoveries to profoundly impact human health. For over 40 years, our research has produced breakthroughs in cancer, neuroscience,immunology and children’s diseases, and is anchored by our NCI-designated cancer center and advanced drug discovery capabilities.

　　The position focuses on the novel approach to study epigenetics at a single cell level. The candidate will explore the capability of Microscopic Imaging of Epigenetic Landscape (MIEL) (Farhy et al., 2018, 2019 biorxiv) and fluorescence-based genetically encoded epigenetic reporters enabling live imaging of epigenetic modifications at a single cell level. MIEL combines fluorescence detection of epigenetic marks with automated cell imaging and machine learning to profile and quantify the “epigenetic signatures” of individual cells. The Postdoctoral Associate will investigate the epigenetic heterogeneity at the single cell level and the asymmetry during stem cell division in different systems including normal and neoplastic neural stem cells focusing on the epigenetic function of SOX2, as wel as normal and pathological (Alzheimer) aging process.

　　A long-standing question of this project is to determine whether the outcome of stem cell division is stochastic or deterministic and whether such outcome could be prospectively predicted based on the epigenetic landscape of the mother cell.