英国曼彻斯特大学前列腺癌生物学博士后招聘

　　招聘简介：

　　工作时间：固定期限为3年

　　关于工作：

　　我们正在寻找一位积极进取的博士后科学家加入Baena博士的前列腺生物学组，研究炎症对前列腺肿瘤起始的作用以及如何预防他们进展为转移性前列腺癌。

　　前列腺癌（PCa）是全球男性癌症相关死亡率的第二大原因，占所有男性癌症死亡人数的15％。 PCa患者在临床和生物学上具有很高的异质性临床行为;一些人患有惰性疾病，而另一些人则患有致命疾病。尽管对雄激素剥夺疗法的初始反应几乎是普遍的，但是进展到去势抗性状态是不可避免的并且是致命的。

　　我们实验室以前的工作表明了进一步了解导致去势抵抗性前列腺癌的分子事件的重要性，因为它们是为这些患者开发改进疗法的关键。

　　因此，岗位持有人将致力于确定肿瘤驱动的炎症途径的作用，及其对肿瘤微环境的影响，以促进肿瘤起始和进展至去势抗性阶段。本研究将为前列腺癌患者提供分子和免疫干预预防前列腺肿瘤进展和转移的新途径。

　　英文原文：

　　Duration: Fixed term for 3 years

　　About the role:

　　We are looking for a highly-motivated Postdoctoral Scientist to join Dr Baena’s Prostate Oncobiology group to study the role of inflammation on prostate tumour initiation and how to prevent their progression to metastatic prostate cancer.

　　Prostate cancer (PCa) is the second leading cause of cancer-related mortality in men worldwide, accounting for 15% of all male cancer deaths. PCa patients exhibit a high heterogeneity both clinically and biologically highly variable clinical behaviour; some have indolent disease whilst in others it is lethal. Although the initial response to androgen deprivation therapy is almost universal, progression to castration resistant state is inevitable and lethal.

　　Previous work from our laboratory shows the importance of further understanding molecular events leading to castration-resistant prostate cancer as they’re key for the development of improved therapies for such patients (Barros-Silva et al., 2018; Parry et al., 2018; Baena et al., 2013).

　　Thus, the post holder will work on defining the role of tumour-driven inflammatory pathways, and its impact on tumour microenvironment to promote tumour-initiation and progression to castration-resistant stage. This study will provide new avenues to prevent prostate tumour progression and metastasis by molecular and immune-based interventions for prostate cancer patients.

　　About you:

　　You will have a PhD in a relevant related subject and have research laboratory experience. You will also have profound knowledge in cellular and molecular biology and have experience of working with in vivo cancer models. You will have significant experience of cell culture, particularly in vitro 3D culture systems and handling primary cells. Profound experience in FACS analyses and lineage tracing work is also essential for this position.

　　This is an exciting opportunity for you to be involved in developing and driving the project as well as writing up work for presentation and publication.

　　Why choose Cancer Research UK Manchester Institute?

　　The Cancer Research UK Manchester Institute (www.cruk.manchester.ac.uk), an Institute of The University of Manchester (www.manchester.ac.uk), is a world-leading centre for excellence in cancer research.  The Institute is core funded by Cancer Research UK (www.cancerresearchuk.org), the largest independent cancer research organisation in the world. We are currently situated at the internationally-renowned life sciences campus at Alderley Park in Cheshire England, 15 miles from Manchester, a vibrant and dynamic city surrounded by beautiful countryside.

　　We are partnered with The Christie NHS Foundation Trust (adjacent to the CRUK Manchester Institute, Paterson Building) in South Manchester (www.christie.nhs.uk), one of the largest cancer treatment centres in Europe.

　　The CRUK Manchester Institute is a key part of the Belfast-Manchester Movember Centre of Excellence for Prostate Cancer. As well as bringing together expert researchers and clinicians, the Movember Centres of Excellence will also provide a world-class training ground for the scientists of the future, building a legacy of top prostate cancer researchers in the UK, as well as establishing international collaborations for the brightest minds to tackle the most important questions in prostate cancer research – now and into the future.

　　How to apply?

　　To apply for this position please visit our website: http://www.cruk.manchester.ac.uk/Opportunities/Opportunities-Home

　　For any informal enquiries about this post, please contact Dr Esther Baena, email: esther.baena@cruk.manchester.ac.uk

　　Closing date: Wednesday 13th March 2019.