美国贝勒医学院儿科博士后招聘

　　招聘简介：

　　·贝勒医学院

　　·地点：德克萨斯州休斯顿

　　·职位编号：7055950（参考号：228503KP）

　　·发布日期：2019年2月14日

　　·申请截止日期：开放至填写

　　职位描述

　　Joanna Yi博士在贝勒医学院（BCM）/德克萨斯儿童医院的实验室正在寻找一位才华横溢的博士后助理，与BCM的药物发现中心（CDD）合作开发针对儿科癌症的靶向药物。 Yi实验室旨在通过多学科方法确定儿科癌症中相关的关键目标，包括化学生物学，细胞和分子生物学以及化验开发。初步目标将进一步表征，以了解它们在这些疾病的体外和体内模型中的作用。同时，我们希望生成可能用于临床试验的活性的生物标志物测定。我们可以使用CDD的药物库来筛选我们的目标，包括大量的DNA编码化学库和可用于设计和运行高通量筛选的机器人。

　　·         Baylor College of Medicine

　　·         Location: Houston, TX

　　·         Job Number: 7055950 (Ref #: 228503KP)

　　·         Posting Date: Feb 14, 2019

　　·         Application Deadline: Open Until Filled

　　Job Description

　　Dr. Joanna Yi’s laboratory at Baylor College of Medicine (BCM)/Texas Children’s Hospital is seeking a talented post-doctoral associate to work on developing targeted drugs for pediatric cancers in collaboration with BCM’s Center for Drug Discovery (CDD).  The Yi lab seeks to identify relevant, lynchpin targets in pediatric cancers through a multidisciplinary approach including chemical biology, cell and molecular biology, and assay development. The initial targets will be further characterized to understand their effect in in vitro and in vivo models of those diseases. Concurrently, we want to generate biomarker assays of activity that potentially could be used in clinical trials. We have unique access to screen our targets with the CDD’s drug libraries, including the massive DNA-encoded chemical library and the robotics available to design and run high-throughput screens.

　　Post-doc will work on translational drug discovery for pediatric cancers, including assay development, chemical biology, cell & molecular biology, in collaboration with BCM's Center for Drug Discovery.  Expected work will include use of flow cytometry, apoptosis assays, qPCR, immunoblotting/immunochemistry, kinase and phosphatase assays, cell cycle analysis, biochemical and cell-based assay development (including use of drug and liquid handling devices), and handling primary patient samples. The successful applicant should be highly motivated and ambitious, eager to take ownership of projects and drive them through completion, including thinking about what additional experiments/collaborations are required for publication. This also includes eventually seeking out his/her own funding and/or next career steps.

　　Required: PhD in genetics, cancer biology, molecular biology, or chemical biology.

　　Required:   Hands-on laboratory experience in genetics, cancer biology, or chemical biology, and/or a related field and a track record of quality publications and/or patents in these areas: chromatin immunoprecipitation, assay development (cell-free and cell-based assays), compound management and drug combination experience,  analysis of sequencing/expression data, and  recombinant protein production in bacterial and/or mammalian expression systems.

　　·         The successful applicant should be highly motivated and ambitious, eager to take ownership of projects and drive them through completion, including thinking about what additional experiments/collaborations are required for publication. This also includes eventually seeking out his/her own funding and/or next career steps.

　　·         Must have a strong record of academic and/or industrial distinction and productivity, and be highly motivated and independently functioning.

　　·         Excellent interpersonal skills and works well in a team environment, collaborating and communication well with those within and outside the lab