美国贝勒医学院分子病毒学与微生物学博士后招聘

　　招聘简介：

　　·贝勒医学院

　　·地点：德克萨斯州休斯顿

　　·职位编号：7055947（参考编号：0306698MV）

　　·发布日期：2019年2月14日

　　·申请截止日期：开放至填写

　　职位描述

　　德克萨斯州休斯顿贝勒医学院阿尔克克宏基因组学和微生物研究中心的Joseph Hyser博士实验室正在寻找一位积极主动，富有创造力的博士后研究员。 Hyser实验室研究了病原体和共生细菌对信号转导途径的利用。我们的重点主要是胃肠道，并使用表达荧光生物传感器的细胞系，类器官和体内模型的活体显微镜检查信号分子和第二信使（如钙，cAMP / cGMP，ROS和NO）介导的信号传导。我们最终有兴趣剖析作为病原体疾病表现和共生和益生菌促进健康方面的沟通途径。考生应持有博士学位。或同等学历的微生物学，GI细胞生物学，分子生物学或相关领域，并已发表在同行评审的期刊上。建议使用3D器官培养，钙成像以及使用鼠标作为模型系统。

　　·         Baylor College of Medicine

　　·         Location: Houston, TX

　　·         Job Number: 7055947 (Ref #: 0306698MV)

　　·         Posting Date: Feb 14, 2019

　　·         Application Deadline: Open Until Filled

　　Job Description

　　The Laboratory of Dr. Joseph Hyser of The Alkek Center for Metagenomics and Microbiome Research at the Baylor College of Medicine, Houston, TX is seeking a highly motivated and creative postdoctoral researcher. The Hyser Lab studies the exploitation of signal transduction pathways by pathogens and commensal bacterial. Our focus is primarily on the GI tract and use live microscopy of cell lines, organoids and in vivo models expressing fluorescent biosensors to examine signaling mediated by signaling molecules and secondary messengers such as calcium, cAMP/cGMP, ROS, and NO. We are ultimately interested in dissecting pathways of communication that underlie the disease manifestations of pathogens and health-promoting aspects of commensals and probiotics. Candidates should hold a Ph.D. or equivalent degree in microbiology, GI cell biology, molecular biology, or related field and have published in a peer-reviewed journal(s). Prior experience with 3D organoid cultures, calcium imaging, and using the mouse as a model system is recommended.

　　Required:  PhD degree in microbiology, cell biology, molecular biology, or related fields.

　　Preferred:

　　·         Research experience and/or demonstrated interest in host-microbial interactions.

　　·         Experience in 3D organoids or enteroids.

　　·         Experience in calcium signaling pathways and calcium imaging.

　　·         Experience in mouse models and intravital microscopy.