美国宾夕法尼亚大学生物化学/细胞和分子生物学/免疫学方向博士后招聘

　　Postdoctoral Researcher in DNA Damage Responses and Cancer, laboratory of Dr. Roger Greenberg at the Perelman School of Medicine, University of Pennsylvania.

　　The laboratory of Dr. Roger Greenberg within the Cancer Biology Department at the University of Pennsylvania is seeking postdoctoral researchers to investigate fundamental mechanisms that impact genome integrity and cancer biology. Our group has pioneered novel approaches to dynamically visualize the molecular events responsible for homologous recombination DNA repair in mammalian cells. These methodologies will be used to interrogate canonical homologous recombination DNA repair by BRCA1 and BRCA2 as well as noncanonical homology directed mechanisms of telomere lengthening. We have also recently elucidated mechanisms underlying communication between DNA double-strand breaks and the immune system, which mediate DNA damage activated anti-tumor immune responses.

　　We are looking to appoint accomplished Postdoctoral Researchers in these areas. Candidates will have a PhD and/or MD in Biochemistry, Cell and Molecular Biology, or Immunology and an extensive publication record.

　　Application Instructions

　　Please submit your CV and a cover letter outlining your research interests, career goals and the names of up to three referees to Dr. Roger Greenberg at rogergr@pennmedicine.upenn.edu.

　　For details on our group, please visit our lab website at: http://www.med.upenn.edu/apps/faculty/index.php/p8145566

　　Relevant Publications

　　Harding SM, Benci JL, Irianto J, Discher DE, Minn AJ, and Greenberg RA. Mitotic progression following DNA damage enables pattern recognition within micronuclei, Nature 23:466-470, 2017

　　Verma P, Dilley RL, Zhang TP, Gyparaki MT, Li Y, and Greenberg RA. RAD52 and SLX4 Act Non-epistatically to ensure Telomere Stability During Alternative Telomere Lengthening. Genes Dev 2019 in press

　　Dilley RL, Verma P, Cho NW, Winters HD, Wondisford AR, and Greenberg RA. Break Induced Telomere Synthesis Underlies Homology Directed Telomere Maintenance. Nature 539(7627):54-58, 2016.

　　Cho NW, Dilley RL, Lampson MA, Greenberg RA: Interchromosomal Homology Searches Drive Directional ALT Telomere Movement and Synapsis. Cell 159(1): 108-21, September 2014.

　　Tang J, Cho NW, Cui G, Manion EM, Shanbhag NM, Botuyan MV, Mer G, Greenberg RA: Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination. Nat Struct Mol Biol 20(3): 317-25, March 2013

　　以上内容由知识人网咨询老师整理发布，希望能给遇到此类状况的申请者们一个清晰的方向。想了解更多关于博士后申请的相关资讯，可以登录我们的官方网站