当前位置:知识人网 >> 国外博士后招聘 >> 正文内容

牛津大学细胞和分子生物学博士后招聘
文章来源:知识人网整理       更新时间:2019年01月11日

  Department of Oncology, Weatherall Institute of Molecular Medicine, Oxford

  Grade 7: £32,236 - £39,609 p.a.

  We have an exciting opportunity for a Postdoctoral Researcher in Professor Adrian Harris’s laboratory at the Weatherall Institute for Molecular Medicine, Department of Oncology, Headington Oxford.

  http://www.imm.ox.ac.uk/wimm-research/molecular-oncology/adrian-l-harris

  The development of antiangiogenic therapy has really depended on work in xenografts and transgenic models. Little has been established about the molecular biology and gene expression profiles, heterogeneity and potential genetic changes in tumour vasculature by any modern technology. We hypothesise that there is great heterogeneity in the tumour endothelial population, that it is adaptive and may have a genetic basis.

  We will investigate this using state of the art methodology for endothelial separation and single cell sequencing at DNA level and RNA sequencing. We profile up to 1000 endothelial cells using the Chromium 10 apparatus, which can allow very high throughput sampling of up to 10,000 cells, 70,000 reads each in 24 hours, which will revolutionise our approach to endothelial biology from human cancer.

  Based on these findings we will investigate models for resistance mechanisms and roles of metastasis of newly discovered signalling pathways. There will also be links to clinical samples before and after antiangiogenic therapy to investigate mechanisms of resistance. The cell biology of these new pathways will be investigated using appropriate endothelial cells, either from primary tumours or from mice and we may need to proceed to make appropriate genetic models in the longer run. The expression of these genes will be assessed on the relevant clinical specimens and animal model systems by immunochemistry or RNAscope FISH.

  The postholder will be a postdoctoral level scientist holding or be nearing completion of, a PhD/DPhil in a relevant area. Expertise in cell and molecular biology will be a necessity, along with evidence of previous publications. A Personal Animal Licence would be advantageous for this role.

  This is a full-time post and is available until 30 September 2020 in the first instance.

  All applicants must complete an application form and upload a CV and supporting statement.

  The closing date for applications is 12.00 noon on Wednesday 13 February 2019.

  https://www.recruit.ox.ac.uk/pls/hrisliverecruit/erq_jobspec_version_4.jobspec?p_id=138745

  Closing Date: 13-FEB-2019 12:00

  以上内容由知识人网咨询老师整理发布,希望能给遇到此类状况的申请者们一个清晰的方向。想了解更多关于博士后申请的相关资讯,可以登录我们的官方网站

扫一扫知识人网官方微信订阅号,更多最新学术资讯、博士后招聘信息 一手掌握!国外博士后、访问学者申请免费专业评估,专家答疑解惑,一键关注离世界顶尖大学一步之遥!

快速申请国外博士后(免费评估)


点击这里快速申请国外博士后

点击这里快速申请国外访问学者

知识人网拥有10余年专职国外博士后、访问学者职位服务经验;
世界30000多所大学、研究机构职位机会,学术研究职位专业服务机构;
资深专业顾问将竭诚为博士精英们提供最优质的服务,实现您梦想的阶梯;
全国免费电话欢迎垂询:400-060-0581 直拨电话:010-68168664/68228237/68161776/68227792