美国哥伦比亚大学基因组学/分子遗传学/统计学/生物信息学相关领域博士后招聘

　　Postdoctoral Research Scientist or Postdoctoral Research Fellow

　　A Postdoctoral Research Scientist or Postdoctoral Research Fellow position is available in the laboratory of Dr. Simone Sanna-Cherchi in the Division of Nephrology at Columbia University Irving Medical Center, New York, New York.

　　The Laboratory

　　The Sanna-Cherchi lab is focused on understanding the genetic basis of kidney disease, with special emphasis on congenital malformation of the kidney and urinary tract and primary glomerulonephritis.

　　During the past 12 years Dr. Sanna-Cherchi established a network of investigators across more than 20 countries worldwide recruiting patients for genetic studies. His work spans the entire spectrum of genomics research. To complement his sequencing approaches for human traits, he has developed new mouse models for congenital defects of the urinary tract, and he is using zebrafish modeling to dissect genes within structural variants associated with developmental defects. New venues in the lab involve the integration of human genomics with use of single cell and single nucleus transcriptomics and development of iPSCs from patients carrying mutations causal for kidney disease. His work provided a strong genetic link between pediatric kidney diseases and neurodevelopmental phenotypes, including autism, intellectual disability, schizophrenia, and others, with important repercussions beyond the field of nephrology.

　　His work has been published in the most prestigious journals, including the New England Journal of Medicine (2013,2017), Nature Genetics (2018), the Journal of Clinical Investigation (2015, 2018), the American Journal of Human Genetics (2007, 2012, 2015, 2017), the Journal of the American society of Nephrology (2005, 2009, 2014), Kidney International (2011, 2015) and many others. http://www.ncbi.nlm.nih.gov/pubmed/?term=sanna-cherchi+s ).

　　Dr. Sanna-Cherchi is well funded, with multiple grants from the National Institute of Health, the Department of Defense and others; moreover, he has a strong track record for securing funding for his trainees (American Association of University Women, AAUW Fellowship; KNAW Ter Muelen Grant; Dutch Kidney Foundation Postdoctoral Fellowship; Italian Society of Nephrology Fellowship; American Society of Nephrology Postdoctoral Fellowship; NIDDK F and T grants). Trainees in the lab receive a very competitive salary.

　　The Position

　　We are looking for an ambitious, enthusiastic and motivated researcher to train in a highly dynamic environment with exposure to world-renowned investigators in the field of human genetics, computational genomics, developmental biology, and stem cells research. The candidate will work on human genetics of pediatric kidney disease of broad medical relevance, by using novel state-of-the-art genomic tools to identify rare variants with large effect on the phenotype and integrate genomic approaches with single cell analyses as well as stem cell biology and developmental genetics. The candidate will have his or her own project and will have the opportunity to collaborate with other investigators in the lab working on large-scale genomic data and on functional modeling in vertebrates.

　　Desired Qualifications

　　The desired qualifications for the position are: 1) a M.D. or Ph.D. degree (preferably in Genomics, Molecular Genetics, Statistics, Bioinformatics, Computer Science, Physics, or a related field), and significant experience with large-scale genomic studies; 2) solid skills in at least one programming language (python, perl, R or C/C++); 3) practical experience in large-scale bioinformatics data analysis with familiarity with both microarray and next-generation sequencing data; 4) experience with human-derived pluripotent stem cells; 5) excellent oral and written communication skills; 6) high enthusiasm, a strong work ethic, and a willingness to push the envelope.

　　Please email a curriculum vitae and contact information for three references to: Dr. Simone Sanna-Cherchi, Columbia University Irving Medical Center, Department of Medicine, Division of Nephrology, New York, NY 10032, email: ss2517@cumc.columbia.edu

　　Columbia University is an Equal Opportunity/Affirmative Action employer —Race/Gender/Disability/Veteran.

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