美国纪念斯隆凯特琳癌症中心细胞生物学方向博士后职位招聘

　　Postdoctoral Research Fellows

　　Memorial Sloan Kettering Cancer Center (MSKCC)

　　We are seeking two ambitious, enthusiastic and motivated postdoctoral research fellows to join our team of bioinformaticians, molecular biologists, and pathology, surgery and oncology fellows. Our laboratory focuses on two main areas: i) the identification and functional validation of novel driver genetic alterations based on the analysis of rare cancer types, and ii) understanding the patterns, causes and impact of intra-tumor genetic heterogeneity in cancers.

　　The first position is to lead the validation of novel driver genes in rare types of breast cancer, in particular the mechanistic basis of genetic alterations affecting genes that regulate pH and vesicle trafficking in oncogenesis. Experience and track record in functional genomics and molecular and/or cell biology are required, as is the ability to work independently in a team and to provide innovative solutions to complex problems. Past experience in molecular biology and models to address the identification of driver genetic alterations. Experience in CRISPR/Cas9 systems for knocking out genes and the introduction of specific mutations and fusion genes is highly desirable.

　　The second position is devoted to the final development and implementation of novel single cell genotyping methods, in addition to the single cell copy number analysis methods our lab has developed and validated (Martelotto et al. Nat Med 2017; Xue et al. Nat Med 2017). Experience in single cell sequencing and a PhD in genetics, molecular and/or cell biology or a related field are required. Past experience in the analysis of intra-tumor genetic heterogeneity in cancers would be desirable.

　　For both positions, track record in the field, including publications as the first author, would be a bonus.

　　Our laboratory offers a collegial environment, with access to cutting edge genomics technologies, and our dedicated high performance computing system.

　　The positions are available immediately.

　　For initial informal enquiries, please contact Jorge Reis-Filho (reisfilj@mskcc.org) or Britta Weigelt (weigeltb@mskcc.org). To submit an application, please email Angela Del (dela@mskcc.org).

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