• 知识人焦点
  • 知识人关注
  • 海归学子
  • 学子园地
  • 当前位置:知识人网>> 博士后之家 国外博士后招聘>> 正文内容

    欧洲分子生物学实验室基因组生物学博士后招聘
    文章来源:知识人网整理       更新时间:2018年10月19日

      About the team/job

      The Furlong lab, at EMBL Heidelberg, has a funded post-doctoral position to use natural sequence variation as a perturbation tool to functionally link enhancers to their target genes, and uncover new mechanisms in genome regulation. In our two recent expression QTL (eQTL) studies [1,2], we demonstrated the power of Drosophila population genetics to get to causal variants: the very short blocks of linkage disequilibrium (LD) provides near base-pair resolution to get to causal effects. These studies provide a proof-of-principle to scale up and perform a comprehensive large-scale cis and trans embryonic eQTL study, in a genetically tractable system. Expanding to more genotypes will include rare variants, and also dramatically increase statistical power to analyze trans effects. Given the extensive prior knowledge about gene regulatory networks durng Drosophila embryogenesis, this is a perfect test system for a large scale trans analysis. The results should provide new insights into how the effect of genetic variation propagates through a developmental network, while in other cases is buffered. The project is at the interface of population genetics, genome regulation and developmental biology, and is a collaboration between the groups of Oliver Stegle (computational modelling) and Trudy MacKay. EMBL is a very international, interdisciplinary institute with a very open, collaborative and vibrant culture. Working language is English. See http://furlonglab.embl.de/ for more info about the lab. 1. Cannavo, E. et al. Genetic variants regulating expression levels and isoform diversity during embryogenesis. Nature 541, 402-406 (2017). 2. Schor, I.E. et al. Promoter shape varies across populations and affects promoter evolution and expression noise. Nat Genet 49, 550-558 (2017).

      Your role

      Your role is to lead and drive this exciting project. Initially this will involve the sample collection, in collaboration with the MacKay lab, and then the sequencing at EMBL, with the help of our Genomics Core facility. You would then work in collaboration with the Stegle group to perform the QTL analysis using new computational models. In the second phase of the project, you would perform cutting edge genome engineering (or collaborate with someone in the Furlong group) to experimentally test model predictions.

      You have

      You should have an excellent track record from your Ph.D., with strong expertise in population genetics. You need to be very organized, and be able to lead and drive big ambitious projects, while at the same time being very collaborative and open.

      Why join us

      The Furlong group is a mixture of experimental and computational biologists at the interface of Transcription/Chromatin Biology and Developmental Biology. We have a great working atmosphere with lots of collaborations and friends within the group. The Furlong lab also has an excellent track record for post-docs within the lab obtaining faculty positions (>70% - see the Alumni on the lab’s web site). EMBL is a unique place with a very friendly, collaborative, open door policy. The excellent colleagues and core facilities make your research interesting, productive and fun. We also have an excellent day care on campus.

      What else do I need to know

      For more information on research in the Furlong lab, check out our web page and recent publications. Heidelberg is a lovely international town, located in a central position to explore Europe. 45 minutes from a major international airport (Frankfurt) – 1.5 hr flight to London or Paris

      以上内容由知识人网咨询老师整理发布,希望能给遇到此类状况的申请者们一个清晰的方向。想了解更多关于国外博士后招聘的相关资讯,可以登录我们的官方网站。

    扫一扫知识人网官方微信订阅号,更多最新学术资讯、博士后招聘信息 一手掌握!国外博士后、访问学者申请免费专业评估,专家答疑解惑,一键关注离世界顶尖大学一步之遥!

    快速申请国外博士后(免费评估)


    点击这里快速申请国外博士后

    点击这里快速申请国外访问学者

    知识人网拥有10余年专职国外博士后、访问学者职位服务经验;
    世界30000多所大学、研究机构职位机会,学术研究职位专业服务机构;
    资深专业顾问将竭诚为博士精英们提供最优质的服务,实现您梦想的阶梯;
    全国免费电话欢迎垂询:4000-600-581 直拨电话:010-68168664/68228237/68161776/68227792