• 知识人焦点
  • 知识人关注
  • 海归学子
  • 学子园地
  • 当前位置:知识人网>> 博士后之家 国外博士后招聘>> 正文内容

    法国细胞生物学研究所癌症治疗方向博士后招聘
    文章来源:知识人网       更新时间:2018年09月14日

      Targeting mitotic ubiquitin receptor protein UBASH3B for cancer therapies

      A postdoctoral position is available in the laboratory of Izabela Sumara at the IGBMC in Strasbourg, France: http://www.igbmc.fr/sumara/

      The interest of the lab is to understand molecular mechanisms of cell cycle and maintenance of genome integrity. Our research aims to dissect the role of the ubiquitin code during mammalian cell division and tumorigenesis. The funded project specifically aims at studying the anti-tumor activity of the small molecule inhibitor targeting ubiquitin receptor protein UBASH3B using animal cancer models and dissecting the molecular mechanisms underlying its inhibitory action by various biochemical approaches combined with high-end microscopy.

      The IGBMC is one of the best European research institutes focused on understanding human disease and basic biological mechanisms at the molecular, cellular and animal level and offers state-of-the-art core facilities and a vibrant, international scientific community.

      Applicants should hold a PhD in biology, biochemistry or related areas. Experience in cancer animal models, cell culture and live cell imaging would be an advantage. Motivated, curious and independent individuals interested in joining us in Strasbourg should send a single pdf document with a cover letter stating the past and future research interests, CV and a publication list to Izabela Sumara: sumara@igbmc.fr

      Selected publications:

      Beck J., Maerki S., Posch M., Metzger T., Persaud A., Scheel H., Hofmann K., Rotin D., Pedrioli P., Swedlow J., Peter M. and Sumara I. (2013)

      Ubiquitylation-dependent localization of Polo-like kinase 1 in mitosis.

      Nature Cell Biology. Apr 15 (4): 430-9.

      Genschik P. Sumara I., and Lechner E. (2013)

      The emerging family of CULLIN3-RING ligases (CRL3s): cellular functions and disease.

      EMBO Journal. Aug 28; 32 (17): 2307-20

      Krupina K., Kleiss C., Metzger T., Fournane S., Schmucker S., Hofmann K., Fischer B., Paul N., Porter I.M., Raffelsberger W., Poch O., Swedlow J.R., Brino L. and Sumara I. (2016)

      Ubiquitin receptor protein UBASH3B drives Aurora B recruitment to mitotic microtubules.

      Developmental Cell. Jan 11, 36 (1): 63–78.

      Krupina K., Kleiss C., Awal S., Rodriguez-Hernandez I., Sanz-Moreno V. and Sumara I. (2018)

      UBASH3B-mediated silencing of the mitotic checkpoint: therapeutic perspectives in cancer.

      Molecular and Cellular Oncology. Nov. 2017 30; 5 (2): e1271494, eCollection 2018….

      以上内容由知识人网咨询老师整理发布,希望能给遇到此类状况的申请者们一个清晰的方向。想了解更多关于国外博士后招聘的相关资讯,可以登录我们的官方网站。

    扫一扫知识人网官方微信订阅号,更多最新学术资讯、博士后招聘信息 一手掌握!国外博士后、访问学者申请免费专业评估,专家答疑解惑,一键关注离世界顶尖大学一步之遥!

    快速申请国外博士后(免费评估)


    点击这里快速申请国外博士后

    点击这里快速申请国外访问学者

    知识人网拥有10余年专职国外博士后、访问学者职位服务经验;
    世界30000多所大学、研究机构职位机会,学术研究职位专业服务机构;
    资深专业顾问将竭诚为博士精英们提供最优质的服务,实现您梦想的阶梯;
    全国免费电话欢迎垂询:4000-600-581 直拨电话:010-68168664/68228237/68161776/68227792