英国The Francis Crick Institute 招收 细胞神经生物学博士后

Short summary

A postdoctoral position is available in Sila Ultanir’s laboratory at the Francis Crick Institute. We are looking for an enthusiastic candidate to study microtubule based cargo transport in neuronal dendrites with emphasis of regulations of microtubule associated proteins by phosphorylation. Microtubule modifications, plus tip dynamics, motor proteins and cytoskeleton interacting proteins can regulate cargo transport in neurons. How phosphorylations of diverse microtubule associated proteins alter trafficking of dendritic or axonal cargo is an open question. Successful candidate will study proteins associated with CDKL5 deficiency disorder using live-imaging, protein biochemistry and knockout mouse model techniques. Candidates with live-imaging experience are encouraged to apply.

Ultanir lab studies kinases that function in neuronal development and function. We use chemical genetics, mass spectrometry and biochemistry methods to determine and validate novel kinase substrates to decipher the underlying signalling mechanisms. We use knockout mouse models to investigate kinase’s roles on neuronal function in vivo. We also generate phosphomutant mice, in which kinase substrates are mutated via CRISPR mediated gene editing to non-phosphorylatable forms in order to mimic loss of kinase function.

About us

The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.

An independent organisation, its founding partners are the Medical Research Council (MRC), Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King’s College London.

The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.

The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.