美国费城莫奈尔化学感官中心味觉干细胞的分子机制和肠道“味觉样”簇细胞的信号转导方向博士后

　　Monell Chemical Senses Center

　　A Postdoctoral position is currently available for research in the molecular mechanisms of taste stem cells and the signaling transduction of intestinal “taste-like” tuft cells (see recent representative publications) in the Jiang laboratory at the Monell Chemical Senses Center in Philadelphia. Candidates with a Ph.D. or equivalent degree in molecular biology, genetics, neuroscience, immunology, physiology or a related field are preferred. Experience with molecular biology and small animal surgery techniques is desired but not mandatory. A background in chemosensory research is not required. Compensation is in accordance with NIH stipend standards. This position is supported by NIH and industry grants. Interested applicants should provide a cover letter, a curriculum vitae and the contact information for three references.

　　The Monell Center is a world-renowned institute focusing on taste and smell research. It is closely associated with the University of Pennsylvania and provides a highly vibrant, collegial and intellectually stimulating environment. Research focuses on understanding how the chemical senses function and their importance in everyday life. Monell is an equal opportunity employer and encourages applications from women and minorities. For more information about the Monell Center, please visit our website at www.monell.org.

　　Recent publications:

　　Jiang P, Josue J, Li X, Glaser D, Li W, Brand JG, Margolskee RF, Reed DR, Beauchamp GK. (2012) Major taste loss in carnivorous mammals. Proc Natl Acad Sci USA. 109 (13): 4956-4961

　　Yee KK, Li Y, Redding KM, Iwatsuki K, Margolskee RF, Jiang P. (2013) Lgr5-EGFP marks taste bud stem/progenitor cells in posterior tongue. Stem Cells. 31 (5): 992-1000.

　　Ren W, Lewandowski BC, Watson J, Iwatsuki K, Bachmanov AA, Margolskee RF, Jiang P (2014) Single Lgr5- or Lgr6-expressing taste stem cells generate taste bud cells ex vivo. Proc Natl Acad Sci USA. 111 (46): 16401-16406

　　Lei W, Ren W, Ohmoto M, Urban JF, Matsumoto I, Margolskee RF, Jiang P (2018). Activation of intestinal tuft cell-expressed Sucnr1 triggers type 2 immunity in the mouse small intestine. Proc Natl Acad Sci USA. 115(21):5552-5557.

　　Qualifications:

　　The Monell lab is seeking a highly motivated postdoctoral fellow interested in exploring molecular mechanisms of taste stem cells and the signaling transduction of intestinal “taste-like” tuft cells. Applicants should have a Ph.D. degree. Candidates with a Ph.D. or equivalent degree in molecular biology, genetics, neuroscience, immunology, physiology or a related field are preferred. Experience with molecular biology and small animal surgery techniques is desired but not mandatory. A background in chemosensory research is not required.

　　Application Instructions:

　　Interested applicants should submit the following documents to https://apply.interfolio.com/52117.

　　A cover letter describing your research interest and goal.

　　A curriculum vitae.

　　The contact information of three references

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