美国密歇根大学安娜堡分校药物化学方向博士后职位招聘

　　Postdoctoral Fellow" but we would like to change it to: "Postdoctoral Position in Medicinal Chemistry for Cancer Drug Discovery, University of Michigan, Ann Arbor

　　· University of Michigan

　　· Location: Ann Arbor, MI

　　· Job Number: 7051865

　　· Posting Date: Jul 2, 2018

　　· Application Deadline: Sep 3, 2018

　　Job Description

　　Postdoctoral Position in Medicinal Chemistry

　　for Cancer Drug Discovery

　　University of Michigan, Ann Arbor

　　Job Description

　　Postdoctoral position is available in the laboratory of Prof. Tomasz Cierpicki, University of Michigan, Ann Arbor, to develop small molecule inhibitors for targeted therapies in cancer. We are seeking for highly motivated synthetic organic chemists and medicinal chemists to join a comprehensive drug discovery program. Dr. Cierpicki’s lab. is conducting highly interdisciplinary research focused on pre-clinical development of novel anti-cancer drugs, which covers medicinal chemistry, structural biology, biochemical and biophysical assays, biological and animal studies. We have a strong team of synthetic chemists to support our drug-discovery efforts. The successful candidate will be involved in designing and synthesis of small molecule inhibitors targeting proteins as potential anti-cancer agents with a major focus on synthesis of heterocyclic compounds targeting protein-protein interactions relevant to cancer. The duties will include design and synthesis of new analogues of existing leads to develop biologically active compounds for testing in cancer cells and animals. The candidate must be independent in designing synthetic routes, solving challenging synthetic problems, efficient in synthesizing targeted molecules, including multi-step synthesis.

　　Requirements

　　Applicant must have PhD in synthetic organic chemistry or medicinal chemistry and be a first author on at least 2-3 publications. This position requires extensive experience in designing synthetic routes for new classes of compounds, solving challenging synthetic problems, SAR analysis. Applicant needs an expertise in using HPLC, NMR and MS for organic chemistry applications. Excellent oral and written communication skills in English are required.

　　How to apply

　　Please submit cover letter, CV, and contact information for 2-3 references combined into one PDF file by e-mail to: tomaszc@umich.edu.

　　Contact: Tomasz Cierpicki, PhD, Associate Professor

　　Department of Pathology, University of Michigan

　　Ann Arbor, MI, 48109, USA

　　https://www.pathology.med.umich.edu/index.php?t=page&id=1473

　　e-mail: tomaszc@umich.edu

　　Relevant publications:

　　1. Borkin, D. et al, Complexity of blocking bivalent protein-protein interactions: development of a highly potent inhibitor of the menin-Mixed Lineage Leukemia interaction, J. Med. Chem. 2018, 61(11): 4832.

　　2. Borkin D. et al, Property Focused Structure-Based Optimization of Small Molecule Inhibitors of the Protein-Protein Interaction between Menin and Mixed Lineage Leukemia (MLL). J Med Chem. 2016, 59(3): 892-913.

　　3. Borkin, D. et al., Pharmacologic inhibition of the menin-MLL interaction blocks progression of MLL leukemia in vivo, Cancer Cell, 2015, 27 (4), 589-602.

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