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    加拿大蒙特利尔临床研究机构IRCM生物化学方向博士后职位招聘
    文章来源:知识人网       更新时间:2018年05月16日

    Postdoctoral Position in Phase Separation and Chromatin Organization : Montreal, Canada

    A postdoctoral position is available in the Francis lab to study the role of phase separation in chromatin organization by Polycomb Group (PcG) proteins. Phase separation is rapidly emerging as an important principle underlying the organization of macromolecular structures in cells. This includes the large scale organization of chromatin domains that is likely driven by chromatin modifications and chromatin binding proteins. We are using Drosophila PcG proteins as a model system to understand how phase separation may create the unique chromatin state associated with PcG protein mediated transcriptional repression. The project will use a combination of in vitro reconstitution and in vivo imaging based experiments. A background in biochemistry and/or biophysics, and a willingness to learn new methods and approaches is essential. Experience with chromatin is an asset but not required. Publications relevant to this project are:
    https://www.nature.com/articles/ncomms10291
    http://www.pnas.org/content/109/18/E1063
    The Francis lab is located in the Systems Biology axis of the IRCM, a research institute affiliated with the University of Montreal. Our lab is also affiliated with McGill University. The IRCM is located in the heart of Montreal, a vibrant city in Quebec, Canada. Montreal was voted the best city in the world for graduate students in 2017 (https://www.topuniversities.com/city-rankings/2017).

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