Postdoc Positions Focusing on Transcriptional/Epigenetic Regulation in Cancer Progression : San Antonio, TX, United States

Multiple postdoctoral positions are available in the laboratory of Dr. Jason Liu (http://molecularmedicine.uthscsa.edu/FAC_Profile.aspx?facID=229) in the Department of Molecular Medicine at the University of Texas Health San Antonio. The focus of the lab is studying enhancer function and epigenetic mechanism in gene regulation in breast and prostate cancer progression. Selected candidates will perform highly interdisciplinary and collaborative scientific research in one or more of the following projects, working with human cell lines, mouse models, and clinical samples:

(1) Explore the function and mechanism of signaling-regulated enhancers in breast and prostate cancers, and understand how enhancers are regulated by the crosstalk of different signaling pathways including sex hormones, inflammation signals and metabolic signals;

(2) Decipher the epigenetic and chromatin 3D level changes in enhancers upon developmental/pathological stimuli or during hormone/drug resistance acquisition;

(3) Identify diagnostic/prognostic biomarkers and therapeutic targets for cancer and develop drugs for pre-clinical studies and potential clinical applications.

Our research integrates next-generation sequencing (NGS)-based technologies and bioinformatics tools to investigate the component, epigenetic, and 3D level changes of enhancers in cancers (refer to Cell, 2014 159: 358-373). We are efficiently combining biochemical, cellular, super-resolution imaging, and animal model-related studies with different NGS-based assays. Our research program will help the trainees from both wet and dry lab sides to build up strong expertise and training record in molecular biology and multi-omics (genomics, transcriptomics, proteomics, epigenomics and metabolomics).

Positions require a Ph.D. degree (or equivalent) in biochemistry, cell biology, cancer biology, bioinformatics, or closely related biological sciences. The candidates need to have high motivation and strong molecular biology background. Any prior experience in molecular mechanism studies, patient-derived xenograft (PDX) models, breast/prostate cancer, and computational analyses will be valued.

San Antonio is one of the fastest growing cities. The UT Health SA is the largest university of health science in South Texas and one of four medical schools in the UT System. The affiliated Mays Cancer Center is one of the NCI-designated national cancer centers in the state of Texas. A competitive salary and benefits package will be provided.

To apply:
Please send the application package in one single pdf file including a cover letter briefly describing your previous experience and your future research interest/plan, curriculum vitae with list of publications, and contact information of at least three references to the following email. You are also welcome to send any inquiries or questions you might have.