Postdoctoral Scholar : Cleveland, OH, United States

The Department of Physiology & Biophysics at Case Western Reserve University School of Medicine seeks two motivated postdoctoral scholars to conduct research in the laboratory of Dr. Tingwei Mu.

The lab focuses on proteostasis maintenance of ion channels in the central nervous system. We use a combination of in vitro cell culture, patient-derived neurons, and electrophysiology to study how the proteostasis network regulates the folding, degradation, assembly, trafficking and function of neuroreceptors. Another research focus of the lab is the development of therapeutics that correct the misfolding of pathogenic ion channels, as a therapeutic strategy for the treatment of such protein conformational diseases.

The successful applicant will participate in projects on elucidating molecular basis of ion channel protein quality control in the endoplasmic reticulum. The qualified candidate will also be part of our drug discovery project for neurological diseases. The applicant must have a PhD and/or MD degree in neuroscience, cell biology, molecular biology, biochemistry, biophysics, pharmacology, or related field. One postdoc position is in the field of electrophysiology with experience on patch clamping in mammalian cells, neurons, and brain slices. The other one is in the general field of cell biology and neuroscience.

Interested individuals should send a cover letter, CV, and the names/phone numbers of three people who could provide letters of reference by email to txm210@case.edu….