瑞典哥德堡载脂蛋白L1在肾病中的应用博士后职位

AstraZeneca (AZ) is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialisation of prescription medicines for some of the world's most serious diseases. But we're more than one of the world's leading pharmaceutical companies. At AZ, we're proud to have a unique workplace culture that inspires innovation and collaboration. Here, employees ar e empowered to express diverse perspectives – and are made to feel valued, energised and rewarded for their ideas and creativity.

We're currently looking for talented scientists to join our innovative academic-style Postdoc. From our centre in Gothenburg, SE, you'll be in a global pharmaceutical environment, contributing to live projects right from the start. You'll take part in a comprehensive training programme, including a focus on drug discovery and development, given access to our existing Postdoctoral research, and encouraged to pursue your own independent research in cutting edge laboratories. It's a newly expanding programme spanning a range of therapeutic areas across a wide range of disciplines.

APOL1 is associated with various and aggressive forms of chronic kidney diseases in people with African ancestry carrying two copies of the mutated APOL1 gene, but its biology and role are not fully elucidated and are an area of active and high profile research in a number of laboratories worldwide. One emerging hypotheses is that APOL1 mutated protein exerts its toxic role in kidney cells through altered handling of lipids and cholesterol. You'll drive AZ efforts in exploring this hypothesis by evaluating lipid handling in human engineered iPS-derived kidney cells expressing APOL1 mutations, by performing molecular and omics analyses to expand mechanistic understanding of APOL1 biology, and by conducting pharmacological in vitro studies to effectively modulate APOL1 function and preserve cellular health. Your work may lead to identification of specific pathways affected by APOL1 and leading to kidney cells dysfunction and death, and to therapeutic intervention points to address APOL1-associated nephropathies. This work is highly significant because of the strong unmet medical need in people with APOL1-associated nephropathies and the high scientific interest on this topic in the nephrology community . You'll work in close collaboration with your AZ supervisors and with your external supervisor, Prof Alessia Fornoni from University of Miami, world leading expert in the role of lipid dysfunction in chronic kidney diseases. You'll also work in different groups within AZ ranging from the stem cells unit to bioinformatics and have the opportunity to learn a variety of techniques.

As a world leader in cardiovascular, renal and metabolic medicines, we're always working on innovative new drugs that will change lives across the globe. To make that happen, we employ a small molecule and new modalities research and development strategy with three priorities: heart failure, diabetes and chronic kidney disease. You'll focus your efforts on making real progress toward slowing, stopping or curing some of the most aggressive diseases that face humanity today. APOL1-associated nephropathies are an area of high unmet medical need. Your work will contribute to elucidate the pathological mechanisms of APOL1 and will potentially lead to identification of intervention points to protect kidney cells and ultimately slow down disease progression. Come and join us in this ambitious undertake.

You'll be accountable for building and implementing the experimental strategy for addressing the primary scientific question of this post-doc. You'll conduct all experimental activities related to this project, including human iPS-cell expansion and differentiation, assessment of lipid and cholesterol handling, omics analyses and in vitro pharmacology studies. You'll have to effectively collaborate with various teams within AZ and at University of Miami to generate, analyse and interpret the data. You'll be also responsible for abstracts, oral presentations and manuscripts preparation and submission.

Essential Education and Experience:

• A PhD or equivalen t qualification in Biological sciences or related areas

Desirable:

• Knowledge in chronic kidney diseases highly preferred

Skills and Capabilities:

• In vitro cell biology, with special focus on human stem cells
• Assessment of lipid and cholesterol handling in vitro
• Ability to run biochemistry, RNA and protein analyses, and high-content imaging
• Understanding of high content data analyses (bioinformatics) analyses and techniques
• Proven communications skills, including writing of manuscripts and oral presentation
• Fluent english (oral and written)
• Ability to work in highly interactive, fast pace environment and independently reach out and connect with relevant stakeholders

This is a 3 year programme. 2 years will be a Fixed Term Contract, with a 1 year extension which will be merit based. The role will be based at Gothenburg, SE with a competitive salary on offer. To apply for this position, please click the apply link below.

Advert opening date – 5th March 2018 / Advert closing date – 13th May 2018

AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law