• 知识人焦点
  • 知识人关注
  • 海归学子
  • 学子园地
  • 当前位置:知识人网>> 博士后之家 国外博士后招聘>> 正文内容

    美国髓系疾病转移开发博士后研究员
    文章来源:知识人网       更新时间:2018年03月12日

    Postdoc Fellow, Translational Development - Myeloid Diseases

    Req #: 1700450
    Location: San Francisco, CA US
    Job Category: Research and Early Development
    Work Location: 1500 Owens Street Suite 600 SAN FRAN 94158
    Organization: Celgene Corporation
    Schedule: 40
    Shift:
    Employee Status: Full time
    Job Type: Other
    Job Level:
    Travel:
    Other Locations:US- CA- San Francisco- Owens Street Celgene

    Description

     

    Celgene is a global biopharmaceutical company leading the way in medical innovation to help patients live longer, better lives. Our purpose as a company is to discover and develop therapies that will change the course of human health.  We value our passion for patients, ​quest for innovation, spirit of independence and love of challenge. With a presence in more than 70 countries, and growing - we look for talented people to grow our business, advance our science and contribute to our unique culture.

     

     

    Translational Development at Celgene

    Celgene Corporation, headquartered in Summit, New Jersey, is an integrated global biopharmaceutical company engaged in the discovery, development and commercialization of novel therapies for the treatment of cancer and inflammatory diseases.  At Celgene, we seek to deliver truly innovative and life-changing drugs for our patients. Investigational compounds are being studied for patients with hematological and solid tumor cancers, including multiple myeloma, myelodysplastic syndromes (MDS), acute myeloid leukemia (AML), chronic lymphocytic leukemia (CLL), non-Hodgkin's lymphoma (NHL), pancreatic cancer and lung cancer.

     

    Translational Development is a department within the Research and Development organization that facilitates the transition of drug candidates from drug discovery through clinical development by enabling rational determination of dose-schedule and responsive patient populations, based on deep understanding of drug mechanism of action. The function additionally explores mechanisms of resistance, rational drug combinations and product differentiation. The San Francisco-based late stage myeloid translational group supports multiple disease areas, including MDS, AML and beta thalassemia. This group leads the development of translational strategies to support the development, and maximize the potential, of Celgene therapies and conduct post-clinical proof-of-concept studies, including registrations and life-cycle management.

     

    Summary/Scope

    We are seeking a talented postdoctoral fellow in the Translational Development and Diagnostics group based in San Francisco, CA to explore the role of iron homeostasis in myeloid disorders.  The candidate will use a variety of tools, ranging from in vivo models of disease, primary cell culture and in vitro systems to understand the effect of various therapeutics on iron regulation in congenital anemias, myeloid neoplasms and/or myeloproliferative disorders.

     

    Responsibilities will include, but are not limited to, the following:

    Plan and conduct experiments to characterize iron metabolism in a variety of biological systems, including 2D and 3D immortalized and primary cell cultures. Characterize iron homeostasis in physiologically relevant in vivo disease models of anemia and cancer. Establish ex vivo cell culture and other systems to test hypotheses related to iron regulation.  Prepare and deliver presentations within the department and externally. Author study reports and peer-reviewed publications

     

    Skills/Knowledge Required:

    Ph.D. degree in molecular and cellular biology, genetics, physiology, or a related discipline and at least 1 year of laboratory experience. iron metabolism, red blood cell biology, and/or the pathophysiology of anemia and myeloproliferative disorders. A track record of rigorous bench research and independent thinking, with at least one first-author publication. Highly motivated to contribute to the development of therapeutics for unmet medical needs. Experience with small animal work. Multiparameter flow cytometry. Bone marrow, liver and other primary cell culture systems. Knowledge of transcriptional profiling, proteomics, or metabolomics would be a plus. Enthusiasm to work in a team-based, collaborative environment. Strong verbal and written communication and organization skills. Ability to prioritize and manage time efficiently.

     

    Prerequisites:  Ph.D. in a scientific discipline with at least 1 year of laboratory experience, preferred.

     

    Note: Postdocs will be eligible for Celgene benefits but will not be entitled to receive Celgene equity, bonuses or annual merit increases.  Minimum relocation assistance will be offered on a case by case basis only.

     

    #LI-POST

     

     

    Celgene is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Celgene complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Celgene in the U.S.

     

    知识人网访问学者名校榜持续更新中

    知识人网博士后捷报榜持续更新中

    更多博士后访学名校经典案例欢迎点击访问知识人网(www.zsr.cc),咨询国外博士后申请、访问学者申请、公派访问学者申请、医学访问学者申请可点击快速在线咨询或拨打全国咨询热线4000-600-668,资深顾问一对一答疑解惑。

    扫一扫知识人网官方微信订阅号,更多最新学术资讯、博士后招聘信息 一手掌握!国外博士后、访问学者申请免费专业评估,专家答疑解惑,一键关注离世界顶尖大学一步之遥!

    快速申请国外博士后(免费评估)


    点击这里快速申请国外博士后

    点击这里快速申请国外访问学者

    知识人网拥有10余年专职国外博士后、访问学者职位服务经验;
    世界30000多所大学、研究机构职位机会,学术研究职位专业服务机构;
    资深专业顾问将竭诚为博士精英们提供最优质的服务,实现您梦想的阶梯;
    全国免费电话欢迎垂询:4000-600-668 直拨电话:010-68228237/68161776/68227792/68168664