意大利米兰ERC资助的博后职位（计算和Wet） - 免疫组织学

We are recruiting computational and wet postdocs in the Genomics of the Innate Immune System Lab of Renato Ostuni at the San Raffaele-Telethon Institute for Gene Therapy (SR-Tiget) in Milan, Italy. Our group combines single-cell genomics, genome engineering and gene therapy to dissect and manipulate the complex network of transcription factors, chromatin regulators and non-coding RNAs that control gene expression in the innate immune system.

The Project
In response to environmental cues, macrophages acquire specialized phenotypes ranging from immune stimulation and cytotoxicity to immune suppression and tissue repair. Aberrant transitions between these properties in cancer underlie the generally pathogenic role of tumor-associated macrophages (TAMs). At the same time, TAM plasticity could be targeted for therapeutic purposes. Within an ERC-funded project, we aim to elucidate how TAMs integrate complex environmental stimuli in tumors and translate them into tissue- and disease-specific gene expression programs. Successful candidates will employ single-cell genomics, computational modelling and CRISPR-based functional screenings to develop cell and gene therapy strategies that functionally repurpose TAMs in pancreatic cancer.

The Candidate
We look for highly motivated, curious and self-driven individuals to lead challenging projects tackling fundamental biological questions in a truly translational environment. We invite applications from candidates with computational or experimental background and: documented experience in statistics/programming/quantitative biology or immunology/genomics; communication and organization skills; ability to work independently within a multidisciplinary team.

We offer highly competitive salaries and benefits. Candidates should send a detailed CV, a cover letter with research interests and motivation to join the lab, and contact information for 2/3 referees to Renato Ostuni (ostuni.renato@hsr.it).

The Institute
SR-Tiget is a world-leading Centre for gene and cell therapy. A joint venture of the Telethon Foundation and the San Raffaele Scientific Institute in Milan, it is located at the heart of one of Europe’s major science parks and research hospitals. Its unique location ensures access to state-of-the-art research facilities and its mission gives priority to clinical translation.

References
Piccolo et al.; Nat Immunol 2017; Ostuni et al., Semin Immunol 2016; Ostuni et al., Trends Immunol. 2015; Ostuni et al., Cell 2013; Zanoni et al., Cell 2011; Zanoni et al., Nature 2009….