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德国人群表观遗传学和表观遗传学博后职位
文章来源:知识人网       更新时间:2017年09月11日

A post-doc position is available in the Johannes group (www.johanneslab.org) at the Technical of University Munich, Germany.
Description: DNA methylation is an important epigenetic mark with fundamental roles in gene regulation and transposable element silencing. In plant genomes, aberrant DNA methylation changes (i.e. epimutations) can arise spontaneously, similar to DNA sequence mutations. Unlike in animals, these epimutations are often transmitted across many generations and have been shown to contribute to the heritability of important plant traits. It remains unclear to which extent epimutations contribute to plant evolution, and whether they are exploitable in agricultural breeding programs. One current aim of our group is to quantify the genetic and environmental factors that shape the rate and the molecular spectrum of spontaneous epimutations in the model plant A. thaliana. In collaboration with other groups we are in the processes of setting up several experimental systems that will allow us to study these questions in depth. We will use whole genome bisulphite sequencing (WGBS) to measure the methylomes of a large number of A. thaliana lines.
What are we looking for: We are looking for a talented post-doc who will take charge of the analysis and interpretation of a large number of WGBS datasets. The applicant would make use of and combine several in-house computational algorithms into a single analysis pipeline. We have a strong preference for bioinformaticians/computational biologists with a deep appreciation for biological phenomena or, alternatively, experimentalists with a solid background in bioinformatics/computational biology. For specific inquiries regarding this position contact Frank Johannes at work@johanneslab.org.
Location: We are embedded in the Plant Sciences department within the TUM School of Life Sciences located (Freising campus). We are also part of the prestigious TUM Institute for Advanced Study. The TUM is rated among the best in Germany and ranked well internationally. The Freising Life Sciences campus is located about 20 minutes from the city center of Munich and 10 minutes from the Munich international airport. The campus has state of the art facilities for plant phenotyping, computing and bioinformatics.
Application: Send your application directly to work@johanneslab.org. The application should include: 1) a full CV, 2) a short statement of research interests and experience, and 3) contact information for two references (preferably everything in a single pdf file). Starting date is November 2017, but applications will be accepted until the position is filled.
Salary: The position is funded initially for 1 years with a possible extension. The salary is 75%-100% of a standard E13 TV-L pay scale depending on qualifications. The TUM is interested in fostering career opportunities for women, therefore women are strongly encouraged to apply. Applicants with disabilities and more or less equal qualifications will be favoured.

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