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    英国伦敦MiNA治疗高级研究员
    文章来源:知识人网       更新时间:2017年08月21日

    MiNA Therapeutics is seeking a highly motivated and talented Senior Research Scientist to join its research team developing novel therapeutics in the field of RNA activation. The candidate will join a small multidisciplinary team sitting at the core of MiNA’s drug development effort which includes supporting its first clinical candidate MTL-CEBPA.

    Job Title: Senior Research Scientist
    Location: iHub, White City, London, UK
    Salary: Competitive

    Main duties and responsibilities:
    • Establish cell-based assays for selecting and optimising oligonucleotides for RNA activation
    • Design and conduct pharmacodynamic analysis and mode of action studies
    • Manage external collaborations including CROs and academic collaborators
    • Help develop and validate new therapeutic opportunities
    • General laboratory support working collaboratively with other team members

    Qualifications:
    • PhD in biological sciences or equivalent
    • At least 3 years Post-doc or industry research experience in life science with a track record of publications

    Skills and Experience required:
    • Sterile mammalian tissue culture essential with experience with both primary cells e.g. hepatocytes, immune cells as well as established cell lines
    • Molecular and cell biology techniques including quantitative PCR, Western blot and ELISA, RNA/DNA/protein extraction from cells and tissues, molecular cloning, quantitative protein/nucleotide interaction assays,
    • Experience of DNA or RNA transfection of cell lines is essential
    • Experience with oligonucleotide based therapeutics is preferred
    • Experience working with microarray sequencing platforms or data generated from multiplex platforms highly desirable
    • Experience of working with acrylamide and non-denaturing agarose for RNA analysis highly desirable
    • Experience of immunobiolgy and/or bioinformatics skills is highly desirable
    • Excellent written and verbal communication with ability to present data clearly and accurately
    • Good organisation, planning, and problem solving skills

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