美国田纳西州达拉斯癌症遗传学表观遗传学和生物标志物博士研究员

The laboratory headed by Ajay Goel, PhD focuses on understanding the interplay between genetic and epigenetic alterations in colorectal, pancreatic, gastric and esophageal cancers. We are a multidisciplinary research group, undertaking a number of collaborative projects involving large international consortia. The projects will involve any/all of the following research focuses.

● Exploration of the role of aberrant DNA methylation, histone modifications and non-coding RNAs (miRNA, lncRNAs, snoRNAs, piRNAs etc.) in gastrointestinal cancers.
● Establishment of innovative methodologies for the development of epigenetic and non-coding RNAs-based biomarkers for the earlier diagnosis, prognosis and predictive responses to chemotherapy in gastrointestinal neoplasia.
● A better understanding of the translational and clinical role of genetic and epigenetic signatures in gastrointestinal cancers.
● Understanding the genetic basis of early-onset and familial colorectal cancers.
● Chemoprevention of gastrointestinal cancers using dietary nutraceuticals, non-steroidal anti-inflammatory drugs (NSAIDs), and other drugs.
● Molecular mechanisms of cancer chemotherapy, stem cells, chemo-resistance and chemo-sensitization.
● Gut microbiome, and its influence on gastrointestinal cancers.

An ideal candidate should have a strong background in biochemistry and/or molecular biology, and relevant experience in cancer genetics and epigenetics. The candidates with prior hands-on experience in sequencing-based platforms (Ion Torrent PGM sequencer, MiSeq/HiSeq, RRBS, ChIP-Seq, MeDip and RNASeq etc.) and other array-based platforms will be given preference.

Under general supervision of the Director of the Center, the Post-Doctoral Fellow will continue to expand upon his/her previous research project. The Post-Doc will present seminars on his/her work-in progress and make informative presentations on scientific articles at Journal Club. The position will continue to focus on developing the skills necessary to obtain grants and scientific publications and become an independent Investigator.

• Location/Facility – Baylor Research Institute, Dallas TX
• Specialty/Department/Practice – Research – Gastrointestinal Cancers
• Shift/Schedule – Full Time, Day Shift (M-F)
• Benefits – Our competitive benefits package includes*:
o Immediate eligibility for health and welfare benefits
o 401(k) savings plan with dollar-for-dollar match up to 5%
o Tuition Reimbursement
o PTO accrual beginning Day 1