英国Bristol大学研究助理职位

Job number: ACAD102700
Division/School: School of Cellular and Molecular Medicine
Contract type: Open ended contract staff
Working pattern: Full time
Salary: £32,004 – £36,001 per annum

Please note: This is a “rolling advert” with a nominal close date only. Applications are welcome at any time and the timing of the selection process will be dependent on the applications received. We will be reviewing applications until these positions are filled.

Postdoctoral positions in mammalian cell competition

Two Wellcome Trust funded post-doc positions in mammalian cell competition are available to join the group of Eugenia Piddini at the School of Cellular and Molecular Medicine, University of Bristol, UK (http://research-information.bristol.ac.uk/en/persons/eugenia-piddini(d9edf159-92ca-4b42-8bd6-6dbe1de23195).html).

The Piddini group studies the mechanisms and function of cell competition and investigates how cell competition can be harnessed to identify novel therapeutic opportunities in cancer and in regenerative medicine. Using epithelial-derived cell lines and mouse primary airway epithelial cells, our group has recently shown that p53 activation induces crowding-hypersensitivity and leads to the elimination of cells by neighbouring cells with low p53 levels. We are now seeking to appoint two outstanding post-docs to expand this work in two directions:

1) Investigate the mechanisms of mechanical cell competition. For this project we are seeking applicants with broad expertise in mammalian cell biology, molecular biology and signal transduction. Prior expertise in the field of mechano-sensing, mechano-transduction and cytoskeletal organisation and remodelling would be a definite plus.

2) Investigate how to exploit cell competition to improve engraftment and repopulation of the airways for regenerative medicine approaches. This project will include both in vitro and in vivo work, using mouse models. The in vivo work will be done in collaboration with the group of Emma Rawlins at the University of Cambridge. For this project we are seeking applicants with expertise in mouse models (including preferably procedures in vivo) and cultures of primary cells.

Applicants should be highly motivated and have a substantial track record of productivity and international experience. They should have a PhD in a relevant subject area, or be close to completion of their degree.

To apply, please click on the Apply button to be redirected to our website, enter the vacancy number into the job search and follow the link to the online application process.