A PhD or Postdoctoral position in Biochemistry at IOCB : Praha 6, Czech Republic

PhD/Postdoctoral position in Biochemistry is available in Dr. Jan Konvalina's lab at the Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences in Prague, Czech Republic.

Hepatitis B virus infection represents a global health problem affecting millions people worldwide. Current therapies include nucleot(s)ide analogues that control but do not eliminate HBV infection. The key factor to this persistence is an intracellular HBV replication intermediate – covalently closed circular (ccc) DNA, which resides in the nucleus of infected cells as a non-integrated plasmid-like molecule and serves as a transcriptional template for HBV. Despite intensive research, the contribution of HBV proteins to the development and regulation of chronic infection is poorly understood and strategies for cccDNA degradation and elimination are limited. The successful candidate will be part of a research team studying mechanisms of cccDNA elimination. The project involves development of nanoparticles for delivery of CRISPR/Cas9 as well as development of other cell-based strategies targeting cccDNA.

IOCB is an excellent European institute with state of the art facilities and an international and stimulating atmosphere to accomplish your goals. Prague is an excellent place to live.