法国巴黎自身免疫性疾病中控制细胞因子产生B细胞的细胞和分子机制博后职位

Our team is investigating the cellular and molecular mechanisms implicated in autoimmune diseases. We have a long-standing focus on the investigation of the role of B cells as suppressors and drivers of immunity through the production of cytokines. We previously found that B cells could regulate immunity through provision of IL-10 and IL-35 (Nature Immunology 2002, Immunity 2010, Nature 2014), and established that the major B cell subsets producing these cytokines in vivo were two distinct subsets of antibody-secreting cells (Immunity 2010, Nature 2014). We have also established that B cells contributed to the pathogenesis of autoimmune disease through the production of IL-6 (J Exp Med 2012). The project will address the molecular mechanisms controlling the expression of cytokines in B cells, and the phenotype of cytokine-producing B cells using novel reporter mouse models. An important part of the project will also involve the characterization of cytokine-producing B cells in human autoimmune disorders, in the frame of established collaborations with clinical groups on the campus. The project will use a combination of molecular and cellular in vitro as well as in vivo approaches. The Institut Necker Enfants Malades (INEM) provides with its two departments in immunology and cellular biology, and its intimate partnership with the IMAGINE institute, an excellent environment to conduct these studies. The laboratory “Immunity in Health and Disease” is within the Necker-Enfants Malades Hospital at the interface between fundamental and clinical research, and the long-term goal of the project is to derive tools useful in the clinic.

The project is funded by a European Research Council (ERC) grant. The candidate should have a strong track record in the field of cellular immunology, or molecular biology. Expertise in experimental models of autoimmunity is highly welcome.

The position is open. Salary will be according to experience following INSERM regulation.