Post-doc : Cleveland, United States

Post-doctoral position at the Interface of Immunology and Cancer Nanotechnology

The Steinmetz Laboratory at Case Western Reserve University School of Medicine |steinmetzlab.com | is seeking talented post-doctoral fellows to develop and study a virus-based nanotechnologies targeting cancer.

Nanoscale engineering is revolutionizing the way we prevent, detect and treat diseases. Viruses are playing a special role in these developments because they can function as prefabricated nanoparticles naturally evolved to deliver cargos to cells and tissues. Our laboratory has developed a library of plant virus-based nanoparticles; through structure-function studies we are beginning to understand how to tailor these materials appropriately for biomedical applications. Through synthetic biology, we have developed virus-based delivery system carrying contrast agent and/or therapeutic cargo enabling therapeutic applications targeting cancer and cardiovascular diseases. Another avenue is the development of virus-like particle platforms for cancer immunotherapy. For some references, we would like to highlight the following publications:

• our situ vaccination technology Nature Nanotechnology 2016, 11, 295-303,
• drug delivery system ACS Nano 2016, 10, 4119-4126,
• and molecular imaging probes Nano Letters 2014, 14, 1551-1558.

In particular, we seek to hire talented post-doctoral candidates with expertise and interest in:
(i) Molecular imaging and drug delivery
(ii) Cancer Immunotherapy