Postdoctoral Training Fellow - Genome-Wide Analysis of Genome Instability : London, United Kingdom

Postdoctoral Training Fellow

Genome-wide analysis of genome instability

This is a full-time fixed term position for 4 years on Crick Terms & Conditions of Employment
Salary between £33,500 – £36,500 per annum.

Context

The Francis Crick institute (the Crick) is a partnership between the Medical Research Council (MRC), Cancer Research UK (CRUK), the Wellcome Trust, University College London (UCL), Imperial College London and King’s College London. It is a registered charity whose purpose is to conduct biomedical research into all aspects of human health and disease.

The Institute will be a world-leading centre of biomedical research and innovation. It will promote connections between researchers and disciplines and between academic institutions, healthcare organisations and businesses. Dedicated to research excellence, the institute will have the scale, vision and expertise to tackle the most challenging scientific questions underpinning health and disease. It will be world-class with a strong national role — training scientists and developing ideas for public good. On 1 April 2015, staff from the London Research Institute (CRUK) and National Institute for Medical Research (MRC) transferred to the Crick to form a fully functional research institute on four sites. In 2016, the Crick will move to a single new, purpose built research centre in St. Pancras which will house some 1,500 staff.

The Francis Crick Institute is a new research institute with a distinct vision of how biomedical research is conducted. It is one of the most significant projects in UK biomedical science for a generation. The institute’s laboratories have an international reputation for cutting edge research into basic biology and are committed to training the next generation of research scientists. The four-year Postdoctoral Training programme is part of this commitment and nearly half of the Postdoctoral Fellows leave to set up their own research groups. Postdocs also benefit from living and working in one of the world’s greatest scientific, cultural and cosmopolitan capital cities.

We seek a talented and motivated postdoc in the area of enome-wide analysis of genome instability to join Dr. Jesper Svejstrup’s laboratory.

Organisation

Dr Svejstrup’s laboratory focuses on transcription-associated genome instability. 

Research techniques used in the laboratory include: Biochemistry (including SILAC proteomics) and modern genome-wide techniques (ChIP-Seq, RNA-Seq, GRO-Seq, etc).

Objectives

The research aims to understand the connection between transcription and the induction of genome instability at the genome-wide level.

In this project, some of the specific aims could include but not limited to:

• How the epigenome affects genome stability in transcribed regions
• How specific chromatin-modifying enzymes affect genome stability
• Development of new genome-wide techniques for assessing transcription-associated genome instability

Person Specification

The post holder should embody and demonstrate our core Crick values: Bold, Imaginative, Open, Dynamic and Collegial, in addition to the following:

Essential

• PhD in Biochemistry, Molecular Biolofy, Oncology, or similar.
• Good knowledge and experience in transcription-, gene expression-, or genome instability research.
• Technical expertise in genome-wide technology, including bioinformatics.
• Track record of writing papers as evidenced by publications or submitted manuscripts in referred journals
• Evidence of data presentation at scientific meetings
• Experience of experimental design
• Ability to work independently and also capable of interacting within a group

Desirable

• Experience in research with model biological system
• Experience in disease biology
• Experience in preparing samples for advanced sequencing.

All Postdoctoral Training Fellows are expected to lead on their own projects and contribute to other projects on a collaborative basis, both within the laboratory and with collaborators. The ability to work as part of a team is essential.