美国杰克逊实验室招聘哺乳动物的基因重组机制方向博士后

Drs. Ken Paigen and Petko Petkov at The Jackson Laboratory, in Bar Harbor, Maine have an open postdoctoral position for research on the protein complexes regulating the initiation of recombination in mammalian systems. Their work centers on the role of the zinc finger protein, PRDM9, which determines the location of mammalian recombination hotspots, and its interacting proteins, using physical, biochemical, genomic and genetic approaches. The group is a well-funded, moderately sized, congenial group that values intellectual freedom and innovation.

Some representative publications are listed; a PubMed search will provide others.

-Baker CL, Petkova PM, et al. (2015). Multimer formation explains allelic suppression of PRDM9 recombination hotspots. PLoS Genet. (in press).
-Walker M, Billings T, et al. (2015). Affinity-seq detects genome-wide PRDM9 binding sites and reveals the impact of prior chromatin modifications on mammalian recombination hotspot usage. Epigenetics and Chromatin (in press).
-Baker CL, Kajita S, et al. (2015). PRDM9 drives evolutionary erosion of hotspots in Mus musculus through haplotype-specific initiation of meiotic recombination. PLoS Genet. 11(1):e1004916.
-Baker CL, Kajita S, et al. (2014). PRDM9 binding organizes hotspot nucleosomes and limits Holliday junction migration. Genome Res. 24(5):724-732.
-Billings T., Parvanov ED, et al. (2013). "DNA binding specificities of the long zinc-finger recombination protein PRDM9." Genome Biol. 14(4): R35.
-Parvanov ED, Petkov PM, Paigen K. (2010). "Prdm9 controls activation of mammalian recombination hotspots." Science 327(5967): 835.
-Paigen, K. and P. Petkov (2010). "Mammalian recombination hot spots: properties, control and evolution." Nat Rev Genet 11(3): 221-233.
-Paigen K., Szatkiewicz JP, et al. (2008). "The recombinational anatomy of a mouse chromosome." PLoS Genet 4(7): e1000119.

Required Skills:
Ability to plan, execute and analyze an independent research project as well as exceptional verbal and written communication skills.

Required Experience:
Ph.D. in the life sciences is required, and a strong background in molecular biology is preferred.

The Jackson Laboratory (www.jax.org) is an independent, nonprofit biomedical research institution and National Cancer Institute-designated Cancer Center with more than 1,500 employees. Headquartered in Bar Harbor, Maine, it has a facility in Sacramento, Calif., and a new genomic medicine institute in Farmington, Conn. Its mission is to discover precise genomic solutions for disease and empower the global biomedical community in the shared quest to improve human health. A strong postdoctoral training program is in place with ample opportunities for both formal and informal training in mouse genetics. The Jackson Laboratory offers a unique research and training environment characterized by scientific collaboration, unparalleled mouse resources, outstanding core services, and a major meeting center that attracts top scientists from around the world.

Applications should include a cover letter describing research interests and background, a CV, and names of three references. Apply online at www.jax.org/careers/postdoc (select link for Bar Harbor positions, position #5130).