Postdoctoral positions are available in the laboratory of Kyunghee Koh at Thomas Jefferson University in Philadelphia to study the molecular and neural basis of sleep and circadian rhythms in Drosophila. Sleep is an essential, evolutionarily conserved process, and Drosophila sleep is an exciting new research area with many opportunities. Creative and highly motivated individuals with a recent Ph.D. in neurobiology, genetics, biochemistry, cell biology, electrophysiology, and/or molecular biology and a strong publication record are encouraged to apply. To apply, please send CV, a letter describing research experience and career goals, and contact information for three references to kyunghee.koh at jefferson.edu

Selected publications:

Afonso DJS, Liu D, Machado DR, Pan H, Jepson JEC, Rogulja D, Koh K. (2015). TARANIS functions with Cyclin A and Cdk1 in a novel arousal center to control sleep in Drosophila. Current Biology. 25.

Liu S, Lamaze A, Liu Q, Tabuchi M, Yang Y, Fowler M, Bharadwaj R, Zhang J, Bedont J, Blackshaw S, Lloyd TE, Montell C, Sehgal A, Koh K*, Wu MN*. (2014). WIDE AWAKE mediates the circadian timing of sleep onset. Neuron. 82: 151-66. *Co-corresponding authors.

Jepson JEC, Shahidullah M, Liu D, le Marchand S, Liu S, Wu MN, Levitan IB, Dalva MB, Koh K. (2014). Regulation of synaptic development and function by the Drosophila PDZ protein DYSCHRONIC. Development. 141:4548-57.

Jepson JEC, Shahiddullah M, Lamaze A, Peterson D, Pan H, Koh K. (2012). dyschronic, a Drosophila homolog of a deaf-blindness gene, regulates circadian output and Slowpoke channels. PLoS Genetics. 8(4):e1002671.

Wu MN, Joiner WJ, Dean T, Yue Z, Smith CJ, Chen D, Hoshi T, Sehgal A, Koh K. (2010). SLEEPLESS, a Ly-6/neurotoxin family member, regulates levels, localization, and activity of Shaker. Nature Neuroscience, 13, 69-75.

Koh K*, Joiner WJ*, Wu MN*, Yue Z, Smith CJ, Sehgal A. (2008). Identification of SLEEPLESS, a novel sleep promoting factor. Science, 321, 372-376. *Equal contribution.

Koh K, Zheng X, Sehgal A. (2006). JETLAG resets the Drosophila circadian clock by promoting light-induced degradation of TIMELESS. Science. 312, 1809-1812.

Koh K, Evans JM, Hendricks JC, Sehgal A. (2006). A Drosophila model for age-associated changes in sleep:wake cycles. Proceedings of the National Academy of Sciences, USA. 103, 13843-13847….